No relationship of lipid-lowering agents to hematoma growth: Pooled analysis of the intensive blood pressure reduction in acute cerebral hemorrhage trials studies

Miriam Priglinger, Hisatomi Arima, Craig Anderson, Martin Krause, J. Chalmers, C. S. Anderson, Y. Huang, J. G. Wang, H. Arima, P. Bath, S. Davis, J. Kim, R. Lindley, B. Neal, L. B. Morgenstern, S. MacMahon, M. Woodward, K. Butcher, B. Chambers, G. DonnanC. Levi, M. W. Parsons, N. Dorsch, Y. Huang, J. G. Wang, C. Lu, S. Chen, J. D. Jiang, Z. Liu, J. Zhang, L. Kong, Y. Song, Z. Wang, W. Wang, F. Wu, Y. Yuan, J. S. Kim, J. Kim, J. Simes, G. Hankey, K. Jamrozik, S. Johnston, L. Shunwei, C. Skulina, B. Peng, L. Billot, Q. Li, S. Su, S. Heritier, E. Heeley, H. Capper, J. Chisholm, R. Currie, J. Fathers, M. Hackett, S. Homewood, K. Jane, K. Jones, S. Leksuwat, B. Mullane, S. Pandey, A. Patel, A. Quilkey, J. Scott, G. Starzec, A. Wadham, S. Zeckendorf, D. Han, S. Ying, W. Xu, L. J. Zhang, Q. Huang, Y. Li, L. Yan, S. Kyung

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Controversy persists over statins and risk of intracerebral hemorrhage. We determined associations of premorbid lipid-lowering therapy and outcomes among participants of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT). Methods: The pooled data of INTERACT 1 and 2 (international, multicenter, prospective, open, blinded end point, randomized controlled trials of patients with intracerebral hemorrhage [<6 hours] and elevated systolic blood pressure) were analyzed with regard to associations of baseline lipid-lowering treatment and clinical outcomes of 3184 participants in a multivariate model. Associations of lipid-lowering therapy and hematoma growth (baseline to 24 hours) in computed tomographic substudies participants (n=1310) were estimated in ANCOVA. Results: Among 204 patients (6.5%) with baseline lipid-lowering treatment, 90-day clinical outcomes were not significantly different after adjustment for confounding variables including region and age. In the computed tomographic substudy, 24-hour hematoma growth was greater in 124 patients (9%) with, compared with those without, prior lipid-lowering therapy. However, this association was not significant between groups (9.2 versus 6.8 mL; P<0.13), after adjustment for prior antithrombotic therapy. Conclusions: No independent associations were found between lipid-lowering medication and adverse outcomes in patients with intracerebral hemorrhage.

Original languageEnglish (US)
Pages (from-to)857-859
Number of pages3
JournalStroke
Volume46
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Cerebral hemorrhage
  • HMG-CoA
  • Statins

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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    Priglinger, M., Arima, H., Anderson, C., Krause, M., Chalmers, J., Anderson, C. S., Huang, Y., Wang, J. G., Arima, H., Bath, P., Davis, S., Kim, J., Lindley, R., Neal, B., Morgenstern, L. B., MacMahon, S., Woodward, M., Butcher, K., Chambers, B., ... Kyung, S. (2015). No relationship of lipid-lowering agents to hematoma growth: Pooled analysis of the intensive blood pressure reduction in acute cerebral hemorrhage trials studies. Stroke, 46(3), 857-859. https://doi.org/10.1161/STROKEAHA.114.007664