No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities

A. V. Moorman; S. C. Raimondi; C. H. Pui; A. Baruchel; A. Biondi; A. J. Carroll; E. Forestier; P. S. Gaynon; J. Harbott; D. O. Harms; N. Heerema; R. Pieters; M. Schrappe; L. B. Silverman; E. Vilmer; C. J. Harrison

doi:10.1038/sj.leu.2403695

No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities

A. V. Moorman, S. C. Raimondi, C. H. Pui, A. Baruchel, A. Biondi, A. J. Carroll, E. Forestier, P. S. Gaynon, J. Harbott, D. O. Harms, N. Heerema, R. Pieters, M. Schrappe, L. B. Silverman, E. Vilmer, C. J. Harrison

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16 Scopus citations

Abstract

This study characterized the additional chromosomal abnormalities (ACA) associated with 11q23 rearrangements in 450 infants and children with acute lymphoblastic leukemia (ALL) and examined the impact of these ACA on survival. Overall, 213 (47%) cases had ACA but the incidence varied according to patient age and 11q23 subgroup. Infants and patients with t(4;11)(q21;q23) had the lowest incidence of ACA (50/182 (27%) and 57/216 (26%) respectively), whereas patients with del(11)(q23) had the highest incidence (66/93 (71%)). Del(11)(q23) abnormalities were heterogeneous and occasionally secondary to t(9;22)(q34;q11.2). Thus, patients with del(11)(q23) comprised a separate biological entity, which was clearly distinct from those with an 11q23 translocation. The most frequent specific ACA were trisomy X (n=38), abnormal 12p (n=32), abnormal 9p (n=28) and del(6q) (n=19). The presence of ACA did not change the 5 year event-free survival estimates among children (56% (95% CI 46-65%) vs 62% (54-69%)) or infants (22% (15-29%) vs 18% (9-29%)), nor when the different 11q23 subgroups were analyzed separately. This study has conclusively demonstrated that there is no prognostic effect of secondary chromosomal changes in association with 11q23 abnormalities in childhood ALL. However, characterization of these ACA is important to determine their potential role in initiation of MLL driven leukemogenesis.

Original language	English (US)
Pages (from-to)	557-563
Number of pages	7
Journal	Leukemia
Volume	19
Issue number	4
DOIs	https://doi.org/10.1038/sj.leu.2403695
State	Published - Apr 2005
Externally published	Yes

Keywords

11q23
Acute lymphoblastic leukemia
Childhood
Cytogenetics
Infant
MLL

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1038/sj.leu.2403695

Cite this

Moorman, A. V., Raimondi, S. C., Pui, C. H., Baruchel, A., Biondi, A., Carroll, A. J., Forestier, E., Gaynon, P. S., Harbott, J., Harms, D. O., Heerema, N., Pieters, R., Schrappe, M., Silverman, L. B., Vilmer, E., & Harrison, C. J. (2005). No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities. Leukemia, 19(4), 557-563. https://doi.org/10.1038/sj.leu.2403695

Moorman, AV, Raimondi, SC, Pui, CH, Baruchel, A, Biondi, A, Carroll, AJ, Forestier, E, Gaynon, PS, Harbott, J, Harms, DO, Heerema, N, Pieters, R, Schrappe, M, Silverman, LB, Vilmer, E & Harrison, CJ 2005, 'No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities', Leukemia, vol. 19, no. 4, pp. 557-563. https://doi.org/10.1038/sj.leu.2403695

@article{3143dd795c7343c6a0739466553afb4d,

title = "No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities",

abstract = "This study characterized the additional chromosomal abnormalities (ACA) associated with 11q23 rearrangements in 450 infants and children with acute lymphoblastic leukemia (ALL) and examined the impact of these ACA on survival. Overall, 213 (47%) cases had ACA but the incidence varied according to patient age and 11q23 subgroup. Infants and patients with t(4;11)(q21;q23) had the lowest incidence of ACA (50/182 (27%) and 57/216 (26%) respectively), whereas patients with del(11)(q23) had the highest incidence (66/93 (71%)). Del(11)(q23) abnormalities were heterogeneous and occasionally secondary to t(9;22)(q34;q11.2). Thus, patients with del(11)(q23) comprised a separate biological entity, which was clearly distinct from those with an 11q23 translocation. The most frequent specific ACA were trisomy X (n=38), abnormal 12p (n=32), abnormal 9p (n=28) and del(6q) (n=19). The presence of ACA did not change the 5 year event-free survival estimates among children (56% (95% CI 46-65%) vs 62% (54-69%)) or infants (22% (15-29%) vs 18% (9-29%)), nor when the different 11q23 subgroups were analyzed separately. This study has conclusively demonstrated that there is no prognostic effect of secondary chromosomal changes in association with 11q23 abnormalities in childhood ALL. However, characterization of these ACA is important to determine their potential role in initiation of MLL driven leukemogenesis.",

keywords = "11q23, Acute lymphoblastic leukemia, Childhood, Cytogenetics, Infant, MLL",

author = "Moorman, {A. V.} and Raimondi, {S. C.} and Pui, {C. H.} and A. Baruchel and A. Biondi and Carroll, {A. J.} and E. Forestier and Gaynon, {P. S.} and J. Harbott and Harms, {D. O.} and N. Heerema and R. Pieters and M. Schrappe and Silverman, {L. B.} and E. Vilmer and Harrison, {C. J.}",

note = "Funding Information: AVM and CJH would like to thank the Leukaemia Research Fund in the UK for financial support. The work was also supported in part by grants (CA21765, CA36401, CA51001, CA78224, CA60419 and GM61393) from the US National Institutes of Health, the American Cancer Society FM Kirby Clinical Research Professorship (to CH Pui) and the American Lebanese Syrian Associated Charities (ALSAC).",

year = "2005",

month = apr,

doi = "10.1038/sj.leu.2403695",

language = "English (US)",

volume = "19",

pages = "557--563",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "4",

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TY - JOUR

T1 - No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities

AU - Moorman, A. V.

AU - Raimondi, S. C.

AU - Pui, C. H.

AU - Baruchel, A.

AU - Biondi, A.

AU - Carroll, A. J.

AU - Forestier, E.

AU - Gaynon, P. S.

AU - Harbott, J.

AU - Harms, D. O.

AU - Heerema, N.

AU - Pieters, R.

AU - Schrappe, M.

AU - Silverman, L. B.

AU - Vilmer, E.

AU - Harrison, C. J.

N1 - Funding Information: AVM and CJH would like to thank the Leukaemia Research Fund in the UK for financial support. The work was also supported in part by grants (CA21765, CA36401, CA51001, CA78224, CA60419 and GM61393) from the US National Institutes of Health, the American Cancer Society FM Kirby Clinical Research Professorship (to CH Pui) and the American Lebanese Syrian Associated Charities (ALSAC).

PY - 2005/4

Y1 - 2005/4

N2 - This study characterized the additional chromosomal abnormalities (ACA) associated with 11q23 rearrangements in 450 infants and children with acute lymphoblastic leukemia (ALL) and examined the impact of these ACA on survival. Overall, 213 (47%) cases had ACA but the incidence varied according to patient age and 11q23 subgroup. Infants and patients with t(4;11)(q21;q23) had the lowest incidence of ACA (50/182 (27%) and 57/216 (26%) respectively), whereas patients with del(11)(q23) had the highest incidence (66/93 (71%)). Del(11)(q23) abnormalities were heterogeneous and occasionally secondary to t(9;22)(q34;q11.2). Thus, patients with del(11)(q23) comprised a separate biological entity, which was clearly distinct from those with an 11q23 translocation. The most frequent specific ACA were trisomy X (n=38), abnormal 12p (n=32), abnormal 9p (n=28) and del(6q) (n=19). The presence of ACA did not change the 5 year event-free survival estimates among children (56% (95% CI 46-65%) vs 62% (54-69%)) or infants (22% (15-29%) vs 18% (9-29%)), nor when the different 11q23 subgroups were analyzed separately. This study has conclusively demonstrated that there is no prognostic effect of secondary chromosomal changes in association with 11q23 abnormalities in childhood ALL. However, characterization of these ACA is important to determine their potential role in initiation of MLL driven leukemogenesis.

AB - This study characterized the additional chromosomal abnormalities (ACA) associated with 11q23 rearrangements in 450 infants and children with acute lymphoblastic leukemia (ALL) and examined the impact of these ACA on survival. Overall, 213 (47%) cases had ACA but the incidence varied according to patient age and 11q23 subgroup. Infants and patients with t(4;11)(q21;q23) had the lowest incidence of ACA (50/182 (27%) and 57/216 (26%) respectively), whereas patients with del(11)(q23) had the highest incidence (66/93 (71%)). Del(11)(q23) abnormalities were heterogeneous and occasionally secondary to t(9;22)(q34;q11.2). Thus, patients with del(11)(q23) comprised a separate biological entity, which was clearly distinct from those with an 11q23 translocation. The most frequent specific ACA were trisomy X (n=38), abnormal 12p (n=32), abnormal 9p (n=28) and del(6q) (n=19). The presence of ACA did not change the 5 year event-free survival estimates among children (56% (95% CI 46-65%) vs 62% (54-69%)) or infants (22% (15-29%) vs 18% (9-29%)), nor when the different 11q23 subgroups were analyzed separately. This study has conclusively demonstrated that there is no prognostic effect of secondary chromosomal changes in association with 11q23 abnormalities in childhood ALL. However, characterization of these ACA is important to determine their potential role in initiation of MLL driven leukemogenesis.

KW - 11q23

KW - Acute lymphoblastic leukemia

KW - Childhood

KW - Cytogenetics

KW - Infant

KW - MLL

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U2 - 10.1038/sj.leu.2403695

DO - 10.1038/sj.leu.2403695

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AN - SCOPUS:20244385139

SN - 0887-6924

VL - 19

SP - 557

EP - 563

JO - Leukemia

JF - Leukemia

IS - 4

ER -

No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities

Abstract

Keywords

ASJC Scopus subject areas

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