No non-sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load

Thomas Bogenrieder; Marijke R. van Dijk; Willeke A M Blokx; Katrin Ramrath; Kees Seldenrijk; Wilhelm Stolz; Paul J. Van Diest

doi:10.1111/j.1365-2559.2011.03931.x

No non-sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load

Thomas Bogenrieder, Marijke R. van Dijk, Willeke A M Blokx, Katrin Ramrath, Kees Seldenrijk, Wilhelm Stolz, Paul J. Van Diest

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Aims: Most melanoma patients with a positive sentinel node (SN) undergo completion lymph node dissection and frequently experience associated morbidity. However, only 10-30% of SN-positive patients have further lymph node metastases. The aim of the present study was to predict the absence of non-SN metastases in a multicentre study of patients with a positive SN based on primary melanoma features and SN tumour load. Methods and results: Of 70 SN positive patients, 18 had non-SN metastases. Penetrative depth of metastatic cells into the SN and SN tumour load was assessed by morphometry. None of the 14 patients (20%) with a Breslow thickness 2 had non-SN metastases. Similarly, none of the 15 patients (21%) with a Breslow thickness

Original language	English (US)
Pages (from-to)	318-326
Number of pages	9
Journal	Histopathology
Volume	59
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2559.2011.03931.x
State	Published - Aug 2011
Externally published	Yes

Keywords

Lymph node metastases
Lymph node staging
Melanoma
S-classification
Sentinel lymph node

ASJC Scopus subject areas

Histology
Pathology and Forensic Medicine

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10.1111/j.1365-2559.2011.03931.x

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title = "No non-sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load",

abstract = "Aims: Most melanoma patients with a positive sentinel node (SN) undergo completion lymph node dissection and frequently experience associated morbidity. However, only 10-30% of SN-positive patients have further lymph node metastases. The aim of the present study was to predict the absence of non-SN metastases in a multicentre study of patients with a positive SN based on primary melanoma features and SN tumour load. Methods and results: Of 70 SN positive patients, 18 had non-SN metastases. Penetrative depth of metastatic cells into the SN and SN tumour load was assessed by morphometry. None of the 14 patients (20%) with a Breslow thickness 2 had non-SN metastases. Similarly, none of the 15 patients (21%) with a Breslow thickness ",

keywords = "Lymph node metastases, Lymph node staging, Melanoma, S-classification, Sentinel lymph node",

author = "Thomas Bogenrieder and {van Dijk}, {Marijke R.} and Blokx, {Willeke A M} and Katrin Ramrath and Kees Seldenrijk and Wilhelm Stolz and {Van Diest}, {Paul J.}",

year = "2011",

month = aug,

doi = "10.1111/j.1365-2559.2011.03931.x",

language = "English (US)",

volume = "59",

pages = "318--326",

journal = "Histopathology",

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T1 - No non-sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load

AU - Bogenrieder, Thomas

AU - van Dijk, Marijke R.

AU - Blokx, Willeke A M

AU - Ramrath, Katrin

AU - Seldenrijk, Kees

AU - Stolz, Wilhelm

AU - Van Diest, Paul J.

PY - 2011/8

Y1 - 2011/8

N2 - Aims: Most melanoma patients with a positive sentinel node (SN) undergo completion lymph node dissection and frequently experience associated morbidity. However, only 10-30% of SN-positive patients have further lymph node metastases. The aim of the present study was to predict the absence of non-SN metastases in a multicentre study of patients with a positive SN based on primary melanoma features and SN tumour load. Methods and results: Of 70 SN positive patients, 18 had non-SN metastases. Penetrative depth of metastatic cells into the SN and SN tumour load was assessed by morphometry. None of the 14 patients (20%) with a Breslow thickness 2 had non-SN metastases. Similarly, none of the 15 patients (21%) with a Breslow thickness

AB - Aims: Most melanoma patients with a positive sentinel node (SN) undergo completion lymph node dissection and frequently experience associated morbidity. However, only 10-30% of SN-positive patients have further lymph node metastases. The aim of the present study was to predict the absence of non-SN metastases in a multicentre study of patients with a positive SN based on primary melanoma features and SN tumour load. Methods and results: Of 70 SN positive patients, 18 had non-SN metastases. Penetrative depth of metastatic cells into the SN and SN tumour load was assessed by morphometry. None of the 14 patients (20%) with a Breslow thickness 2 had non-SN metastases. Similarly, none of the 15 patients (21%) with a Breslow thickness

KW - Lymph node metastases

KW - Lymph node staging

KW - Melanoma

KW - S-classification

KW - Sentinel lymph node

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No non-sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load

Abstract

Keywords

ASJC Scopus subject areas

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