No non-sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load

Thomas Bogenrieder, Marijke R. van Dijk, Willeke A M Blokx, Katrin Ramrath, Kees Seldenrijk, Wilhelm Stolz, Paul J. Van Diest

Research output: Contribution to journalArticle

Abstract

Aims: Most melanoma patients with a positive sentinel node (SN) undergo completion lymph node dissection and frequently experience associated morbidity. However, only 10-30% of SN-positive patients have further lymph node metastases. The aim of the present study was to predict the absence of non-SN metastases in a multicentre study of patients with a positive SN based on primary melanoma features and SN tumour load. Methods and results: Of 70 SN positive patients, 18 had non-SN metastases. Penetrative depth of metastatic cells into the SN and SN tumour load was assessed by morphometry. None of the 14 patients (20%) with a Breslow thickness 2 had non-SN metastases. Similarly, none of the 15 patients (21%) with a Breslow thickness

Original languageEnglish (US)
Pages (from-to)318-326
Number of pages9
JournalHistopathology
Volume59
Issue number2
DOIs
StatePublished - Aug 2011
Externally publishedYes

Fingerprint

Tumor Burden
Melanoma
Neoplasm Metastasis
cyhalothrin
Lymph Node Excision
Multicenter Studies
Lymph Nodes
Morbidity

Keywords

  • Lymph node metastases
  • Lymph node staging
  • Melanoma
  • S-classification
  • Sentinel lymph node

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Bogenrieder, T., van Dijk, M. R., Blokx, W. A. M., Ramrath, K., Seldenrijk, K., Stolz, W., & Van Diest, P. J. (2011). No non-sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load. Histopathology, 59(2), 318-326. https://doi.org/10.1111/j.1365-2559.2011.03931.x

No non-sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load. / Bogenrieder, Thomas; van Dijk, Marijke R.; Blokx, Willeke A M; Ramrath, Katrin; Seldenrijk, Kees; Stolz, Wilhelm; Van Diest, Paul J.

In: Histopathology, Vol. 59, No. 2, 08.2011, p. 318-326.

Research output: Contribution to journalArticle

Bogenrieder, T, van Dijk, MR, Blokx, WAM, Ramrath, K, Seldenrijk, K, Stolz, W & Van Diest, PJ 2011, 'No non-sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load', Histopathology, vol. 59, no. 2, pp. 318-326. https://doi.org/10.1111/j.1365-2559.2011.03931.x
Bogenrieder, Thomas ; van Dijk, Marijke R. ; Blokx, Willeke A M ; Ramrath, Katrin ; Seldenrijk, Kees ; Stolz, Wilhelm ; Van Diest, Paul J. / No non-sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load. In: Histopathology. 2011 ; Vol. 59, No. 2. pp. 318-326.
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