No histologic evidence of foetal cardiotoxicity following exposure to maternal hydroxychloroquine

Deborah Friedman, Leif Lovig, Marc K Halushka, Robert M. Clancy, Peter M. Izmirly, Jill P. Buyon

Research output: Contribution to journalArticle

Abstract

It is currently recommended that hydroxychloroquine (HCQ) be maintained during pregnancy in patients with systemic lupus erythematosus. Recent data suggest that this Toll-like receptor inhibitor may also reduce the recurrence rate of anti-SSA/Ro associated congenital heart block (CHB). This case report describes a unique situation in which a CHB-afflicted, HCQ-exposed pregnancy was electively terminated. The heart did not reveal any characteristic features of cardiotoxicity, providing further evidence supporting the safety of foetal exposure to HCQ.

Original languageEnglish (US)
Pages (from-to)857-859
Number of pages3
JournalClinical and Experimental Rheumatology
Volume35
Issue number5
StatePublished - 2017

Keywords

  • Heart block
  • Hydroxychloroquine
  • Lupus
  • Pregnancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

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