No heroin or morphine 6β-glucuronide analgesia in μ-opioid receptor knockout mice

Nobue Kitanaka; Ichiro Sora; Stephen Kinsey; Zhizhen Zeng; George R. Uhl

doi:10.1016/S0014-2999(98)00516-0

No heroin or morphine 6β-glucuronide analgesia in μ-opioid receptor knockout mice

Nobue Kitanaka, Ichiro Sora, Stephen Kinsey, Zhizhen Zeng, George R. Uhl

School of Medicine

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Recent reports suggest that heroin and its metabolite morphine 6β-glucuronide can produce analgesia independent of the morphine-preferring μ-opioid receptor. We have tested heroin and morphine 6β-glucuronide analgesia in wild-type, homozygous and heterozygous μ-opioid receptor knockout mice. Homozygotes display no heroin or morphine 6β-glucuronide analgesia. Heterozygous mice with one μ-opioid receptor gene copy reveal reduced heroin and morphine 6β-glucuronide analgesia. The μ-opioid receptor-dependence of heroin and morphine 6β-glucuronide fails to support a requirement for a heroin-specific opiate receptor subtype. Copyright (C) 1998 Elsevier Science B.V.

Original language	English (US)
Journal	European Journal of Pharmacology
Volume	355
Issue number	1
DOIs	https://doi.org/10.1016/S0014-2999(98)00516-0
State	Published - Aug 14 1998

Keywords

Morphine
Opiate
Pain

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/S0014-2999(98)00516-0

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abstract = "Recent reports suggest that heroin and its metabolite morphine 6β-glucuronide can produce analgesia independent of the morphine-preferring μ-opioid receptor. We have tested heroin and morphine 6β-glucuronide analgesia in wild-type, homozygous and heterozygous μ-opioid receptor knockout mice. Homozygotes display no heroin or morphine 6β-glucuronide analgesia. Heterozygous mice with one μ-opioid receptor gene copy reveal reduced heroin and morphine 6β-glucuronide analgesia. The μ-opioid receptor-dependence of heroin and morphine 6β-glucuronide fails to support a requirement for a heroin-specific opiate receptor subtype. Copyright (C) 1998 Elsevier Science B.V.",

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AU - Sora, Ichiro

AU - Kinsey, Stephen

AU - Zeng, Zhizhen

AU - Uhl, George R.

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AB - Recent reports suggest that heroin and its metabolite morphine 6β-glucuronide can produce analgesia independent of the morphine-preferring μ-opioid receptor. We have tested heroin and morphine 6β-glucuronide analgesia in wild-type, homozygous and heterozygous μ-opioid receptor knockout mice. Homozygotes display no heroin or morphine 6β-glucuronide analgesia. Heterozygous mice with one μ-opioid receptor gene copy reveal reduced heroin and morphine 6β-glucuronide analgesia. The μ-opioid receptor-dependence of heroin and morphine 6β-glucuronide fails to support a requirement for a heroin-specific opiate receptor subtype. Copyright (C) 1998 Elsevier Science B.V.

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No heroin or morphine 6β-glucuronide analgesia in μ-opioid receptor knockout mice

Abstract

Keywords

ASJC Scopus subject areas

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