No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis

Roland Ivo, Thomas G. Schulze, Johannes Schumacher, Kristina Kesper, Daniel J. Müller, Ilana Kremer, Michael Dobrusin, Mustafa Mujaheed, Ibrahim Murad, Monika Blanaru, Isaam Bannoura, Alon Reshef, Rachel Bachner-Melman, Richard P. Ebstein, Peter Propping, Robert H. Belmaker, Wolfgang Maier, Marcella Rietschel, Markus M. Nöthen, Sven Cichon

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: An analysis of 80 British parent-offspring trios by Wei and Hemmings in 2000 revealed thre1e out of five markers within the NOTCH4 locus to be strongly associated with schizophrenia. In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin. METHODS: Our study population comprised a German case-control sample (n=512 schizophrenia patients and n=232 controls) and two independent parent-offspring trio samples of German (n=159 trios) and Palestinian-Arab (n=208 trios) descent. We examined a total of ten single nucleotide polymorphisms within the NOTCH4 locus and the adjacent loci, spanning a region of approximately 100 kb. RESULTS: Neither single marker nor haplotype analyses showed association with schizophrenia. In addition, analyses of the German case-control and trio samples revealed no significant association between NOTCH4 polymorphisms and early-onset schizophrenia. CONCLUSIONS: Our results suggest that NOTCH4 is unlikely to play a major role in the genetic predisposition to schizophrenia in the German or the Palestinian-Arab population.

Original languageEnglish (US)
Pages (from-to)197-203
Number of pages7
JournalPsychiatric Genetics
Volume16
Issue number5
DOIs
StatePublished - Oct 2006
Externally publishedYes

Keywords

  • Age of onset
  • Association analysis
  • NOTCH4
  • Schizophrenia
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

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