No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder

Rami Abou Jamra, Johannes Schumacher, Tim Becker, Faten Dahdouh, Stephanie Ohlraun, Husam Suliman, Thomas G. Schulze, Monja Tullius, Svetlana Kovalenko, Wolfgang Maier, Marcella Rietschel, Peter Propping, Markus M. Nöthen, Sven Cichon

Research output: Contribution to journalArticle

Abstract

The proline dehydrogenase locus must be considered as a positional and functional candidate in schizophrenia. It is located in the chromosomal region of the velocardiofacial syndrome on 22q11 that is suspected to contain genes relevant to schizophrenia, and is involved in the metabolism of neurotransmitters. Positive association between single-nucleotide polymorphisms at the proline dehydrogenase locus and schizophrenia further supported the role of proline dehydrogenase in the development of schizophrenia. In order to replicate these findings, we analyzed three single-nucleotide polymorphisms in a sample comprising 299 schizophrenic patients and 300 controls. In addition, we assessed whether proline dehydrogenase also contributes to bipolar affective disorder, because chromosome 22q11 is also implicated in bipolar affective disorder. We therefore included 300 patients with bipolar affective disorder. This is the first study on a potential involvement of the proline dehydrogenase locus in bipolar affective disorder. Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder.

Original languageEnglish (US)
Pages (from-to)195-198
Number of pages4
JournalPsychiatric Genetics
Volume15
Issue number3
DOIs
Publication statusPublished - Sep 2005
Externally publishedYes

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Keywords

  • Association study
  • Bipolar affective disorder
  • Proline dehydrogenase
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

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