Abstract
The proline dehydrogenase locus must be considered as a positional and functional candidate in schizophrenia. It is located in the chromosomal region of the velocardiofacial syndrome on 22q11 that is suspected to contain genes relevant to schizophrenia, and is involved in the metabolism of neurotransmitters. Positive association between single-nucleotide polymorphisms at the proline dehydrogenase locus and schizophrenia further supported the role of proline dehydrogenase in the development of schizophrenia. In order to replicate these findings, we analyzed three single-nucleotide polymorphisms in a sample comprising 299 schizophrenic patients and 300 controls. In addition, we assessed whether proline dehydrogenase also contributes to bipolar affective disorder, because chromosome 22q11 is also implicated in bipolar affective disorder. We therefore included 300 patients with bipolar affective disorder. This is the first study on a potential involvement of the proline dehydrogenase locus in bipolar affective disorder. Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 195-198 |
| Number of pages | 4 |
| Journal | Psychiatric Genetics |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2005 |
| Externally published | Yes |
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Keywords
- Association study
- Bipolar affective disorder
- Proline dehydrogenase
- Schizophrenia
ASJC Scopus subject areas
- Genetics(clinical)
- Psychiatry and Mental health
- Genetics
- Neuroscience(all)
Cite this
No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder. / Jamra, Rami Abou; Schumacher, Johannes; Becker, Tim; Dahdouh, Faten; Ohlraun, Stephanie; Suliman, Husam; Schulze, Thomas G.; Tullius, Monja; Kovalenko, Svetlana; Maier, Wolfgang; Rietschel, Marcella; Propping, Peter; Nöthen, Markus M.; Cichon, Sven.
In: Psychiatric Genetics, Vol. 15, No. 3, 09.2005, p. 195-198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder
AU - Jamra, Rami Abou
AU - Schumacher, Johannes
AU - Becker, Tim
AU - Dahdouh, Faten
AU - Ohlraun, Stephanie
AU - Suliman, Husam
AU - Schulze, Thomas G.
AU - Tullius, Monja
AU - Kovalenko, Svetlana
AU - Maier, Wolfgang
AU - Rietschel, Marcella
AU - Propping, Peter
AU - Nöthen, Markus M.
AU - Cichon, Sven
PY - 2005/9
Y1 - 2005/9
N2 - The proline dehydrogenase locus must be considered as a positional and functional candidate in schizophrenia. It is located in the chromosomal region of the velocardiofacial syndrome on 22q11 that is suspected to contain genes relevant to schizophrenia, and is involved in the metabolism of neurotransmitters. Positive association between single-nucleotide polymorphisms at the proline dehydrogenase locus and schizophrenia further supported the role of proline dehydrogenase in the development of schizophrenia. In order to replicate these findings, we analyzed three single-nucleotide polymorphisms in a sample comprising 299 schizophrenic patients and 300 controls. In addition, we assessed whether proline dehydrogenase also contributes to bipolar affective disorder, because chromosome 22q11 is also implicated in bipolar affective disorder. We therefore included 300 patients with bipolar affective disorder. This is the first study on a potential involvement of the proline dehydrogenase locus in bipolar affective disorder. Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder.
AB - The proline dehydrogenase locus must be considered as a positional and functional candidate in schizophrenia. It is located in the chromosomal region of the velocardiofacial syndrome on 22q11 that is suspected to contain genes relevant to schizophrenia, and is involved in the metabolism of neurotransmitters. Positive association between single-nucleotide polymorphisms at the proline dehydrogenase locus and schizophrenia further supported the role of proline dehydrogenase in the development of schizophrenia. In order to replicate these findings, we analyzed three single-nucleotide polymorphisms in a sample comprising 299 schizophrenic patients and 300 controls. In addition, we assessed whether proline dehydrogenase also contributes to bipolar affective disorder, because chromosome 22q11 is also implicated in bipolar affective disorder. We therefore included 300 patients with bipolar affective disorder. This is the first study on a potential involvement of the proline dehydrogenase locus in bipolar affective disorder. Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder.
KW - Association study
KW - Bipolar affective disorder
KW - Proline dehydrogenase
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=24144456288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24144456288&partnerID=8YFLogxK
U2 - 10.1097/00041444-200509000-00010
DO - 10.1097/00041444-200509000-00010
M3 - Article
C2 - 16094254
AN - SCOPUS:24144456288
VL - 15
SP - 195
EP - 198
JO - Psychiatric Genetics
JF - Psychiatric Genetics
SN - 0955-8829
IS - 3
ER -