TY - JOUR
T1 - No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia
AU - Nyegaard, Mette
AU - Demontis, Ditte
AU - Thestrup, Britta Boserup
AU - Hedemand, Anne
AU - Sørensen, Karina Meden
AU - Hansen, Thomas
AU - Werge, Thomas
AU - Hougaard, David Michael
AU - Yolken, Robert H.
AU - Mortensen, Preben Bo
AU - Mors, Ole
AU - Børglum, Anders D.
PY - 2012/6
Y1 - 2012/6
N2 - The human endogenous retrovirus HERV-K18 is located within intron 1 of CD48 on chromosome 1q and is still active in the human genome. Genetic variation in HERV-K18 single-nucleotide polymorphisms (SNPs) has previously been associated with an increased risk of schizophrenia (SZ) and with type 2 diabetes (T2D) among individuals with SZ. Here, we present a replication study of association of two SNPs in HERV-K18 and 19 tagSNPs in CD48 with (a) SZ and (b) T2D in patients with SZ in two Danish samples (total number of cases=750 and controls=1214). No association was found with SZ or with T2D among individuals with SZ for any of the investigated SNPs. However, one HERV-K18 SNP showed a tendency toward an association with T2D in younger SZ patients, in agreement with previous findings, but due to a very low sample size, this result needs to be further investigated.
AB - The human endogenous retrovirus HERV-K18 is located within intron 1 of CD48 on chromosome 1q and is still active in the human genome. Genetic variation in HERV-K18 single-nucleotide polymorphisms (SNPs) has previously been associated with an increased risk of schizophrenia (SZ) and with type 2 diabetes (T2D) among individuals with SZ. Here, we present a replication study of association of two SNPs in HERV-K18 and 19 tagSNPs in CD48 with (a) SZ and (b) T2D in patients with SZ in two Danish samples (total number of cases=750 and controls=1214). No association was found with SZ or with T2D among individuals with SZ for any of the investigated SNPs. However, one HERV-K18 SNP showed a tendency toward an association with T2D in younger SZ patients, in agreement with previous findings, but due to a very low sample size, this result needs to be further investigated.
KW - Association
KW - CD48
KW - human endogenous retrovirus
KW - schizophrenia
KW - type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84860272192&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860272192&partnerID=8YFLogxK
U2 - 10.1097/YPG.0b013e328353953c
DO - 10.1097/YPG.0b013e328353953c
M3 - Article
C2 - 22495247
AN - SCOPUS:84860272192
SN - 0955-8829
VL - 22
SP - 146
EP - 148
JO - Psychiatric genetics
JF - Psychiatric genetics
IS - 3
ER -