No association of 9p21 with arterial elasticity and retinal microvascular findings

Aaron R. Folsom, James S. Pankow, Xiaohui Li, Daniel A. Duprez, David R. Jacobs, Ronald Klein, Barbara Klein, Weihong Tang, Tien Yin Wong, Mary Frances Cotch, Kent D. Taylor, Stephen S. Rich, Jennifer L. Hall, Wendy S. Post, Jerome I. Rotter

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: How 9p21 variation affects risk of cardiovascular disease is unclear, so we assessed whether 9p21 variants are associated with arterial elasticity or retinal microvascular findings. Methods: In the prospective Multi-Ethnic Study of Atherosclerosis (MESA) we assessed 378 SNPs in the 9p21 locus. Within four ethnic groups, we used an additive genetic model to relate the 9p21 SNPs to five vascular phenotypes: small and large elasticity derived from radial diastolic pulse contour analysis; Young's elastic modulus from carotid artery ultrasound measurements; and the diameter of the central retinal arteries and veins. Results: In neither ethnic-specific nor pooled data was there any statistically significant association between any of the 9p21 SNPs and any of the five vascular phenotypes. Conclusion: Our study does not support an association of 9p21 variation with arterial elasticity or retinal microvascular abnormalities.

Original languageEnglish (US)
Pages (from-to)301-303
Number of pages3
JournalAtherosclerosis
Volume230
Issue number2
DOIs
StatePublished - Oct 2013

Keywords

  • 9p21 SNP
  • Arterial elasticity
  • Prospective study
  • Retinal microvascular abnormalities

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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