No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples

Beate Glaser, Johannes Schumacher, Hywel J. Williams, Rami Abou Jamra, Nikolai Ianakiev, Radoi Milev, Stephanie Ohlraun, Thomas G. Schulze, Piotr M. Czerski, Joanna Hauser, Erick G. Jönsson, Göran C. Sedvall, Norman Klopp, Thomas Illig, Tim Becker, Peter Propping, Nigel M. Williams, Sven Cichon, George Kirov, Marcella RietschelKieran C. Murphy, Michael C. O'Donovan, Markus M. Nöthen, Michael J. Owen

Research output: Contribution to journalArticlepeer-review

Abstract

Background: It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females (Mukai et al 2004). Methods: We investigated the putative risk allele (rs175174) in four schizophrenia association samples including a Bulgarian proband and parent sample (474 trios) and three case-control panels of European origin (1028 patients/1253 control subjects) in an attempt to replicate these findings. Results: Our results do not support the hypothesis that genetic variation at rs175174 is associated with increased risk for schizophrenia nor do they suggest the presence of gender-specific differences. Conclusions: Our data suggest that the reported genetic association by Mukai et al either represents type I error resulting from sampling variance or that rs175174 is in linkage disequilibrium (LD) with the functional variant for schizophrenia and different LD patterns obscure the detection of association.

Original languageEnglish (US)
Pages (from-to)78-80
Number of pages3
JournalBiological Psychiatry
Volume58
Issue number1
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

Keywords

  • Association
  • Chromosome 22q11
  • Disequilibrium
  • Linkage
  • Schizophrenia
  • VCFS
  • ZDHHC8

ASJC Scopus subject areas

  • Biological Psychiatry

Fingerprint

Dive into the research topics of 'No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples'. Together they form a unique fingerprint.

Cite this