TY - JOUR
T1 - No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample
AU - Fallin, Danielle
AU - Kundtz, Amy
AU - Town, Terrence
AU - Gauntlett, Ann C.
AU - Duara, Ranjan
AU - Barker, William
AU - Crawford, Fiona
AU - Mullan, Michael
N1 - Funding Information:
This work was funded in part by Mr. Robert Roskamp and also NIH grant RO1-AG12412.
PY - 1997/9/19
Y1 - 1997/9/19
N2 - It is now commonly known that possession of the ξ4 allele of the apolipoprotein E (APOE) gene confers an increased risk for both familial and sporadic Alzheimer's disease (AD), in a dose-dependent way. Other genes that may play a role in AD, either through independent association with the disease or through modification of the existing APOE risk, have been reported with conflicting results. One such gene, the low density lipoprotein receptor-related protein (LRP) gene, was recently reported by two groups to be associated with AD, although the groups identified different risk- conferring alleles. Both studies were based on clinic-derived AD populations (one American, one French), and both reported only marginally significant results. We have genotyped a community-based AD and control population at this LRP polymorphism and find no association between the variants at that polymorphism and the occurrence of AD. Further, despite the biochemical relationship between LRP and the ApoE protein, we find no significant statistical interaction between the alleles at these loci.
AB - It is now commonly known that possession of the ξ4 allele of the apolipoprotein E (APOE) gene confers an increased risk for both familial and sporadic Alzheimer's disease (AD), in a dose-dependent way. Other genes that may play a role in AD, either through independent association with the disease or through modification of the existing APOE risk, have been reported with conflicting results. One such gene, the low density lipoprotein receptor-related protein (LRP) gene, was recently reported by two groups to be associated with AD, although the groups identified different risk- conferring alleles. Both studies were based on clinic-derived AD populations (one American, one French), and both reported only marginally significant results. We have genotyped a community-based AD and control population at this LRP polymorphism and find no association between the variants at that polymorphism and the occurrence of AD. Further, despite the biochemical relationship between LRP and the ApoE protein, we find no significant statistical interaction between the alleles at these loci.
KW - Alzheimer's disease risk
KW - Apolipoprotein
KW - Genetic interaction
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U2 - 10.1016/S0304-3940(97)00634-4
DO - 10.1016/S0304-3940(97)00634-4
M3 - Article
C2 - 9350853
AN - SCOPUS:0343632390
VL - 233
SP - 145
EP - 147
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2-3
ER -