No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family-based study of a palestinian Arab population

I. Kremer, M. Rietschel, M. Dobrusin, M. Mujaheed, I. Murad, M. Blanaru, I. Bannoura, D. J. Müller, T. G. Schulze, A. Reshef, S. Gathas, S. Schwab, D. Wildenauer, R. Bachner-Melman, R. H. Belmaker, W. Maier, R. P. Ebstein

Research output: Contribution to journalArticle

Abstract

Several recent meta-analyses appear to show a weak but significant effect of both forms of the gly/ser DRD3 polymorphism in conferring risk for schizophrenia. Since most studies have employed the artifact-prone case-control design, we thought it worthwhile to examine the role of this polymorphism using a robust family-based strategy in an ethnic group not previously systematically studied in psychiatric genetics, Palestinian Arabs. We failed to obtain any evidence in 129 Palestinian triads, using the haplotype relative risk (allele frequency: Pearson chi-square = 0.009, P > 0.1, df = 1, n = 258 alleles) or transmission disequilibrium test design (chi-square = 0.38, P > 0.1, n = 86 families) for association/linkage (or increased homozygosity) of the DRD3 Bal I polymorphism to schizophrenia in our sample. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)778-780
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume96
Issue number6
StatePublished - Dec 4 2000
Externally publishedYes

Keywords

  • Dopamine d3 receptor
  • Genetics
  • Haplotype relative risk
  • Linkage disequilibrium
  • Polymorphism
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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    Kremer, I., Rietschel, M., Dobrusin, M., Mujaheed, M., Murad, I., Blanaru, M., Bannoura, I., Müller, D. J., Schulze, T. G., Reshef, A., Gathas, S., Schwab, S., Wildenauer, D., Bachner-Melman, R., Belmaker, R. H., Maier, W., & Ebstein, R. P. (2000). No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family-based study of a palestinian Arab population. American Journal of Medical Genetics - Neuropsychiatric Genetics, 96(6), 778-780.