No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sample

Alexander Georgi, Rami A. Jamra, Johannes Schumacher, Tim Becker, Christine Schmael, Monika Deschner, Susanne Höfels, Maren Wulff, Markus Schwarz, Norman Klopp, Thomas Illig, Peter Propping, Sven Cichon, Markus M. Nöthen, Marcella Rietschel, Thomas G. Schulze

Research output: Contribution to journalArticlepeer-review

Abstract

Disturbed glutamatergic neurotransmission has been implicated in the pathogenesis of schizophrenia and bipolar disorder, with the N-methy-D-aspartate receptors being in the focus of research. The NR1 subunit, which is encoded by the gene GRIN1, plays a key role in the functionality of N-methy-D-aspartate receptors. We tested the association between GRIN1 and bipolar disorder in a sample of German descent, consisting of 306 bipolar disorder patients and 319 population-based controls. No significant association was found. In accordance with our recent findings, we hypothesized that restricting case definition to individuals with a history of persecutory delusions might clarify the relationship between bipolar disorder and GRIN1. This stratified analysis did not yield any significant association either. Our results do not support an association of the GRIN1 gene with bipolar disorder in the German population.

Original languageEnglish (US)
Pages (from-to)183-184
Number of pages2
JournalPsychiatric Genetics
Volume16
Issue number5
DOIs
StatePublished - Oct 2006
Externally publishedYes

Keywords

  • Bipolar disorder
  • Glutamatergic neurotransmission
  • GRIN1
  • N-methy-D-aspartate receptor

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

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