No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death

James T. Becker, Jeremy J. Martinson, Sudhir Penugonda, Lawrence Kingsley, Samantha Molsberry, Sandra Reynolds, Aaron Aronow, Karl Goodkin, Andrew Levine, Eileen Martin, Eric N. Miller, Cynthia A. Munro, Ann Ragin, Ned Sacktor

Research output: Contribution to journalArticle

Abstract

The ε4 allele of the apolipoprotein E (ApoE) gene may have important interactions with physical health and cognitive function among individuals with HIV disease. The purpose of this study is to examine the relationships between ε4, HIV disease, age, neuropsychological impairment, and death in a large, well-characterized study sample. A total of 2846 men participating in the Multicenter AIDS Cohort Study had ApoE genotyping and neuropsychological test data available for analysis. We found a significant association between HIV infection and time to death (from any cause), as well as older age, race, and education. But, ApoE status was not significantly associated with time to death. Similarly, we found a significant association between HIV infection and time to incident cognitive impairment, as well as age, education, and HIV serostatus; Apoε4 status was not related to incident cognitive impairment. There were no significant interactions between ApoE, HIV infection, and age on cognitive impairment. These data replicate and strengthen prior findings of the lack of association between ApoE ε4 and cognitive outcomes in HIV disease. We conclude that within the specific constraints of an exclusively male study in which the majority of participants were less than 65 years of age (range 22–87 years), it appears reasonable to conclude that the ε4 allele is not significantly interacting with HIV serostatus.

Original languageEnglish (US)
Pages (from-to)24-31
Number of pages8
JournalJournal of neurovirology
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Age
  • ApoE
  • Cognition
  • HIV disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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  • Cite this

    Becker, J. T., Martinson, J. J., Penugonda, S., Kingsley, L., Molsberry, S., Reynolds, S., Aronow, A., Goodkin, K., Levine, A., Martin, E., Miller, E. N., Munro, C. A., Ragin, A., & Sacktor, N. (2014). No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death. Journal of neurovirology, 21(1), 24-31. https://doi.org/10.1007/s13365-014-0290-2