NMR studies of brain 13C-glucose uptake and metabolism: Present status

Peter C.M. van Zijl; Doug Rothman

doi:10.1016/0730-725X(95)02034-Q

NMR studies of brain ¹³C-glucose uptake and metabolism: Present status

Peter C.M. van Zijl, Doug Rothman

School of Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

One of the common features of epilepsy is a change in glucose metabolism at the site of seizure activity during and between seizures. The noninvasive in situ study of glucose transport and metabolism by NMR can potentially provide detailed information about this phenomena. In this short review, we will discuss the principles of ¹³C-glucose NMR studies of the brain and compare the advantages and disadvantages of this method to those of ¹⁸F-deoxyglucose studies using positron emission tomography (PET).

Original language	English (US)
Pages (from-to)	1213-1221
Number of pages	9
Journal	Magnetic Resonance Imaging
Volume	13
Issue number	8
DOIs	https://doi.org/10.1016/0730-725X(95)02034-Q
State	Published - 1995

Keywords

Brain
Glucose metabolism
Glucose transport
Magnetic resonance

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

Access to Document

10.1016/0730-725X(95)02034-Q

Cite this

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title = "NMR studies of brain 13C-glucose uptake and metabolism: Present status",

abstract = "One of the common features of epilepsy is a change in glucose metabolism at the site of seizure activity during and between seizures. The noninvasive in situ study of glucose transport and metabolism by NMR can potentially provide detailed information about this phenomena. In this short review, we will discuss the principles of 13C-glucose NMR studies of the brain and compare the advantages and disadvantages of this method to those of 18F-deoxyglucose studies using positron emission tomography (PET).",

keywords = "Brain, Glucose metabolism, Glucose transport, Magnetic resonance",

author = "{van Zijl}, {Peter C.M.} and Doug Rothman",

note = "Funding Information: Acknowledgments-The authors are grateful for helpful discussions with Drs. Graeme Mason and Robert Shulman on metabolic modelling, and Dr. Kevin Behar on neuronal/glial compartmentation. Dr. Delphine Davis is acknowledged for carefully proofreading the manuscript. Our research is supported by the Whitaker Foundation (P.C.M.V.Z.), and NIH grants NS31490 (P.C.M.V.Z.), NS28790 (D.R.), RR06022 (D.R.), DK34576 (D.R.), DK27121 (D.R.), and NS26419 (D.R.).",

year = "1995",

doi = "10.1016/0730-725X(95)02034-Q",

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pages = "1213--1221",

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TY - JOUR

T1 - NMR studies of brain 13C-glucose uptake and metabolism

T2 - Present status

AU - van Zijl, Peter C.M.

AU - Rothman, Doug

N1 - Funding Information: Acknowledgments-The authors are grateful for helpful discussions with Drs. Graeme Mason and Robert Shulman on metabolic modelling, and Dr. Kevin Behar on neuronal/glial compartmentation. Dr. Delphine Davis is acknowledged for carefully proofreading the manuscript. Our research is supported by the Whitaker Foundation (P.C.M.V.Z.), and NIH grants NS31490 (P.C.M.V.Z.), NS28790 (D.R.), RR06022 (D.R.), DK34576 (D.R.), DK27121 (D.R.), and NS26419 (D.R.).

PY - 1995

Y1 - 1995

N2 - One of the common features of epilepsy is a change in glucose metabolism at the site of seizure activity during and between seizures. The noninvasive in situ study of glucose transport and metabolism by NMR can potentially provide detailed information about this phenomena. In this short review, we will discuss the principles of 13C-glucose NMR studies of the brain and compare the advantages and disadvantages of this method to those of 18F-deoxyglucose studies using positron emission tomography (PET).

AB - One of the common features of epilepsy is a change in glucose metabolism at the site of seizure activity during and between seizures. The noninvasive in situ study of glucose transport and metabolism by NMR can potentially provide detailed information about this phenomena. In this short review, we will discuss the principles of 13C-glucose NMR studies of the brain and compare the advantages and disadvantages of this method to those of 18F-deoxyglucose studies using positron emission tomography (PET).

KW - Brain

KW - Glucose metabolism

KW - Glucose transport

KW - Magnetic resonance

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