NMR investigation of histamine-phospholipid interaction

Darrell Abernethy; Thomas J. Fitzgerald; Edward J. Walaszek

doi:10.1016/S0006-291X(74)80013-6

NMR investigation of histamine-phospholipid interaction

Darrell Abernethy, Thomas J. Fitzgerald, Edward J. Walaszek

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Dispersions of histamine and phosphatidyl-L-serine, phosphatidyl-ethanolamine, and phosphatidylcholine were investigated at acidic and alkaline pD values using nmr. A specific interaction between histamine and phosphatidyl-L-serine was observed in the acidic pD range and involved only the imidazole protons of histamine. No interactions between histamine and the other phospholipids were observed.

Original language	English (US)
Pages (from-to)	535-541
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	59
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(74)80013-6
State	Published - Jul 24 1974
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(74)80013-6

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title = "NMR investigation of histamine-phospholipid interaction",

abstract = "Dispersions of histamine and phosphatidyl-L-serine, phosphatidyl-ethanolamine, and phosphatidylcholine were investigated at acidic and alkaline pD values using nmr. A specific interaction between histamine and phosphatidyl-L-serine was observed in the acidic pD range and involved only the imidazole protons of histamine. No interactions between histamine and the other phospholipids were observed.",

author = "Darrell Abernethy and Fitzgerald, {Thomas J.} and Walaszek, {Edward J.}",

note = "Funding Information: This research was supported by a grant from the Pharmaceutical Manufacturers' Association Foundation and by P.H.S. Grant 1 S04 FRO6147.",

year = "1974",

month = jul,

day = "24",

doi = "10.1016/S0006-291X(74)80013-6",

language = "English (US)",

volume = "59",

pages = "535--541",

journal = "Biochemical and Biophysical Research Communications",

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TY - JOUR

T1 - NMR investigation of histamine-phospholipid interaction

AU - Abernethy, Darrell

AU - Fitzgerald, Thomas J.

AU - Walaszek, Edward J.

N1 - Funding Information: This research was supported by a grant from the Pharmaceutical Manufacturers' Association Foundation and by P.H.S. Grant 1 S04 FRO6147.

PY - 1974/7/24

Y1 - 1974/7/24

N2 - Dispersions of histamine and phosphatidyl-L-serine, phosphatidyl-ethanolamine, and phosphatidylcholine were investigated at acidic and alkaline pD values using nmr. A specific interaction between histamine and phosphatidyl-L-serine was observed in the acidic pD range and involved only the imidazole protons of histamine. No interactions between histamine and the other phospholipids were observed.

AB - Dispersions of histamine and phosphatidyl-L-serine, phosphatidyl-ethanolamine, and phosphatidylcholine were investigated at acidic and alkaline pD values using nmr. A specific interaction between histamine and phosphatidyl-L-serine was observed in the acidic pD range and involved only the imidazole protons of histamine. No interactions between histamine and the other phospholipids were observed.

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U2 - 10.1016/S0006-291X(74)80013-6

DO - 10.1016/S0006-291X(74)80013-6

M3 - Article

C2 - 4853403

AN - SCOPUS:0016243338

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VL - 59

SP - 535

EP - 541

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

NMR investigation of histamine-phospholipid interaction

Abstract

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