NMR-based metabolomics of prostate cancer: a protagonist in clinical diagnostics

Deepak Kumar, Ashish Gupta, Kavindra Nath

Research output: Contribution to journalReview articlepeer-review

Abstract

ABSTRACT: Advances in the application of NMR spectroscopy-based metabolomic profiling of prostate cancer comprises a potential tactic for understanding the impaired biochemical pathways arising due to a disease evolvement and progression. This technique involves qualitative and quantitative estimation of plethora of small molecular weight metabolites of body fluids or tissues using state-of-the-art chemometric methods delivering an important platform for translational research from basic to clinical, to reveal the pathophysiological snapshot in a single step. This review summarizes the present arrays and recent advancements in NMR-based metabolomics and a glimpse of currently used medical imaging tactics, with their role in clinical diagnosis of prostate cancer.

Original languageEnglish (US)
Pages (from-to)651-661
Number of pages11
JournalExpert Review of Molecular Diagnostics
Volume16
Issue number6
DOIs
StatePublished - Jun 2 2016

Keywords

  • MRSI
  • Metabolomics
  • NMR spectroscopy
  • PET
  • clinical intervention
  • prostate cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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