NMDA receptors mediating Fos expression in rat spinal cord induced by subcutaneous injection of formalin

Yuan Xiang Tao, Zhi Qi Zhao

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: To examine the effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptors on noxious stimulation-induced Fos expression in the rat spinal cord. METHODS: Formalin (2%) was injected sc into one hindpaw of the rat. Fos expression was exhibited by immunocytochemical technique. RESULTS: Two hours after sc formalin, Fos-like immunoreactive (FLI) neurons were distributed mainly in medial part of the lamina I and the outer lamina II of the ipsilateral dorsal horn. dl-2-Amino-5-phosphonovalerate (APV) administered intrathecally (10 μl, 0.01, 0.1, or 1 g · L-1) before injection of formalin into a hindpaw reduced the number of FLI neurons dose-dependently in the dorsal horn (P < 0.01), while 6, 7-dinitroquinoxaline-2,3(1H,4H)-dione (DNQX) (1 g · L-1) was ineffective. CONCLUSION: NMDA receptor mediated noxious stimulation-induced Fos expression in the rat spinal cord.

Original languageEnglish (US)
Pages (from-to)506-509
Number of pages4
JournalActa Pharmacologica Sinica
Volume19
Issue number6
StatePublished - Nov 1 1998

Keywords

  • Formaldehyde
  • Immunohistochemistry
  • N-methyl-D-aspartate receptors
  • Pain
  • Proto-oncogene proteins c- fos
  • Spinal cord

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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