NMDA receptor-independent long-term depression correlates with successful aging in rats

Research output: Contribution to journalArticlepeer-review

Abstract

Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plasticity mechanisms.

Original languageEnglish (US)
Pages (from-to)1657-1659
Number of pages3
JournalNature neuroscience
Volume8
Issue number12
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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