NMDA receptor-independent long-term depression correlates with successful aging in rats

Hey Kyoung Lee; Sun Seek Min; Michela Gallagher; Alfredo Kirkwood

doi:10.1038/nn1586

NMDA receptor-independent long-term depression correlates with successful aging in rats

Hey Kyoung Lee, Sun Seek Min, Michela Gallagher, Alfredo Kirkwood

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plasticity mechanisms.

Original language	English (US)
Pages (from-to)	1657-1659
Number of pages	3
Journal	Nature neuroscience
Volume	8
Issue number	12
DOIs	https://doi.org/10.1038/nn1586
State	Published - Dec 2005

ASJC Scopus subject areas

Neuroscience(all)

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title = "NMDA receptor-independent long-term depression correlates with successful aging in rats",

abstract = "Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plasticity mechanisms.",

author = "Lee, {Hey Kyoung} and Min, {Sun Seek} and Michela Gallagher and Alfredo Kirkwood",

note = "Funding Information: This work was supported by a US National Institutes of Health grant (NIA PO1AG09973) to M.G. and A.K.",

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AU - Min, Sun Seek

AU - Gallagher, Michela

AU - Kirkwood, Alfredo

N1 - Funding Information: This work was supported by a US National Institutes of Health grant (NIA PO1AG09973) to M.G. and A.K.

PY - 2005/12

Y1 - 2005/12

N2 - Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plasticity mechanisms.

AB - Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plasticity mechanisms.

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NMDA receptor-independent long-term depression correlates with successful aging in rats

Abstract

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