Nivolumab in NSCLC: Latest evidence and clinical potential

Raghav Sundar; Byoung Chul Cho; Julie R. Brahmer; Ross A. Soo

doi:10.1177/1758834014567470

Nivolumab in NSCLC: Latest evidence and clinical potential

Raghav Sundar, Byoung Chul Cho, Julie R. Brahmer, Ross A. Soo

School of Medicine

Research output: Contribution to journal › Review article › peer-review

151 Scopus citations

Abstract

New insight on the interaction between the immune system and tumor has identified the programmed death-1/programmed death-1 ligand pathway to be a key player in evading host immune response. The immune checkpoint modulator, nivolumab (BMS-936558/ONO-4538), is the first PD-1 inhibitor to gain regulatory approval, for the treatment of patients with unresectable melanoma. This review will discuss results from early phase studies of nivolumab in solid tumors including non-small cell lung cancer (NSCLC) as well as studies of nivolumab in combination with chemotherapy, other immune modulators and molecular targeted therapy in patients with NSCLC.

Original language	English (US)
Pages (from-to)	85-96
Number of pages	12
Journal	Therapeutic Advances in Medical Oncology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1177/1758834014567470
State	Published - Mar 2015

Keywords

immune checkpoint modulator
nivolumab
non-small cell lung cancer
programmed death-1
programmed death-1 ligand

ASJC Scopus subject areas

Oncology

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10.1177/1758834014567470

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title = "Nivolumab in NSCLC: Latest evidence and clinical potential",

abstract = "New insight on the interaction between the immune system and tumor has identified the programmed death-1/programmed death-1 ligand pathway to be a key player in evading host immune response. The immune checkpoint modulator, nivolumab (BMS-936558/ONO-4538), is the first PD-1 inhibitor to gain regulatory approval, for the treatment of patients with unresectable melanoma. This review will discuss results from early phase studies of nivolumab in solid tumors including non-small cell lung cancer (NSCLC) as well as studies of nivolumab in combination with chemotherapy, other immune modulators and molecular targeted therapy in patients with NSCLC.",

keywords = "immune checkpoint modulator, nivolumab, non-small cell lung cancer, programmed death-1, programmed death-1 ligand",

author = "Raghav Sundar and Cho, {Byoung Chul} and Brahmer, {Julie R.} and Soo, {Ross A.}",

note = "Funding Information: RS, BCC and RAS have no conflicts of interest to declare. JBR has received research funding from Merck and BMS, is a paid consultant for Merck and is a compensated advisory board member for BMS. Funding Information: RAS is supported by the National Research Foundation, Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative. ",

year = "2015",

month = mar,

doi = "10.1177/1758834014567470",

language = "English (US)",

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pages = "85--96",

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T2 - Latest evidence and clinical potential

AU - Sundar, Raghav

AU - Cho, Byoung Chul

AU - Brahmer, Julie R.

AU - Soo, Ross A.

N1 - Funding Information: RS, BCC and RAS have no conflicts of interest to declare. JBR has received research funding from Merck and BMS, is a paid consultant for Merck and is a compensated advisory board member for BMS. Funding Information: RAS is supported by the National Research Foundation, Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative.

PY - 2015/3

Y1 - 2015/3

N2 - New insight on the interaction between the immune system and tumor has identified the programmed death-1/programmed death-1 ligand pathway to be a key player in evading host immune response. The immune checkpoint modulator, nivolumab (BMS-936558/ONO-4538), is the first PD-1 inhibitor to gain regulatory approval, for the treatment of patients with unresectable melanoma. This review will discuss results from early phase studies of nivolumab in solid tumors including non-small cell lung cancer (NSCLC) as well as studies of nivolumab in combination with chemotherapy, other immune modulators and molecular targeted therapy in patients with NSCLC.

AB - New insight on the interaction between the immune system and tumor has identified the programmed death-1/programmed death-1 ligand pathway to be a key player in evading host immune response. The immune checkpoint modulator, nivolumab (BMS-936558/ONO-4538), is the first PD-1 inhibitor to gain regulatory approval, for the treatment of patients with unresectable melanoma. This review will discuss results from early phase studies of nivolumab in solid tumors including non-small cell lung cancer (NSCLC) as well as studies of nivolumab in combination with chemotherapy, other immune modulators and molecular targeted therapy in patients with NSCLC.

KW - immune checkpoint modulator

KW - nivolumab

KW - non-small cell lung cancer

KW - programmed death-1

KW - programmed death-1 ligand

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Nivolumab in NSCLC: Latest evidence and clinical potential

Abstract

Keywords

ASJC Scopus subject areas

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