Nitrous Oxide and Fertility

Ronald H. Gray, Andrew S. Rowland, Donna Day Baird, Clarice R. Weinberg, Jay B. Brodsky, Patricia A. Baird

Research output: Contribution to journalLetterpeer-review


To the Editor: The study by Rowland et al. (Oct. 1 issue)1 clearly demonstrated reduced fertility among female dental assistants exposed to high levels of unscavenged nitrous oxide. The authors also reported, but did not comment on, a higher rate of spontaneous abortion (50 percent) in 10 pregnant women exposed to high levels of unscavenged nitrous oxide, as compared with an 8 percent rate of fetal loss in 315 pregnant women with no exposure to nitrous oxide or exposure to a lower level. This difference is significant (P = 0.001 by Fisher's exact test) and suggests that nitrous oxide may…

Original languageEnglish (US)
Pages (from-to)284-285
Number of pages2
JournalNew England Journal of Medicine
Issue number4
StatePublished - Jan 28 1993

ASJC Scopus subject areas

  • Medicine(all)


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