Nitroglycerin and nitroprusside induced changes in cerebral hemodynamics

M. C. Rogers, R. J. Traystman

Research output: Contribution to journalArticle

Abstract

In dogs both nitroglycerin and nitroprusside are capable of elevating cerebral spinal fluid presssure (Pcsf), lowering cerebral perfusion pressure, and decreasing CBF. The increase in Pcsf appears to be independent of changes in CBF since marked increases in Pcsf occurred with no changes in CBF in the normal Pcsf group. This suggests the possibility that these drugs may increase cerebral blood volume and Pcsf via changes in cerebral venous capacitance. From a clinical perspective these studies confirm that both nitroglycerin and nitroprusside, in the presence of an initially elevated Pcsf, may lower cerebral blood flow. Since the patients most likely to receive these drugs often have marginal cerebral perfusion pressure to start, special attention must be paid to the cerebral hemodynamic effects of these agents. Finally, while producing less systemic hypotension, at any given dose range administered nitroglycerin appeared to elevate Pcsf more than did nitroprusside.

Original languageEnglish (US)
JournalAnesthesiology
Volume51
Issue number3 SUPPL
StatePublished - 1979

Fingerprint

Cerebrovascular Circulation
Nitroglycerin
Nitroprusside
Hemodynamics
Pharmaceutical Preparations
Hypotension
Dogs

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Rogers, M. C., & Traystman, R. J. (1979). Nitroglycerin and nitroprusside induced changes in cerebral hemodynamics. Anesthesiology, 51(3 SUPPL).

Nitroglycerin and nitroprusside induced changes in cerebral hemodynamics. / Rogers, M. C.; Traystman, R. J.

In: Anesthesiology, Vol. 51, No. 3 SUPPL, 1979.

Research output: Contribution to journalArticle

Rogers, MC & Traystman, RJ 1979, 'Nitroglycerin and nitroprusside induced changes in cerebral hemodynamics', Anesthesiology, vol. 51, no. 3 SUPPL.
Rogers, M. C. ; Traystman, R. J. / Nitroglycerin and nitroprusside induced changes in cerebral hemodynamics. In: Anesthesiology. 1979 ; Vol. 51, No. 3 SUPPL.
@article{253a7394d48c42bdad2b09521ed2170d,
title = "Nitroglycerin and nitroprusside induced changes in cerebral hemodynamics",
abstract = "In dogs both nitroglycerin and nitroprusside are capable of elevating cerebral spinal fluid presssure (Pcsf), lowering cerebral perfusion pressure, and decreasing CBF. The increase in Pcsf appears to be independent of changes in CBF since marked increases in Pcsf occurred with no changes in CBF in the normal Pcsf group. This suggests the possibility that these drugs may increase cerebral blood volume and Pcsf via changes in cerebral venous capacitance. From a clinical perspective these studies confirm that both nitroglycerin and nitroprusside, in the presence of an initially elevated Pcsf, may lower cerebral blood flow. Since the patients most likely to receive these drugs often have marginal cerebral perfusion pressure to start, special attention must be paid to the cerebral hemodynamic effects of these agents. Finally, while producing less systemic hypotension, at any given dose range administered nitroglycerin appeared to elevate Pcsf more than did nitroprusside.",
author = "Rogers, {M. C.} and Traystman, {R. J.}",
year = "1979",
language = "English (US)",
volume = "51",
journal = "Anesthesiology",
issn = "0003-3022",
publisher = "Lippincott Williams and Wilkins",
number = "3 SUPPL",

}

TY - JOUR

T1 - Nitroglycerin and nitroprusside induced changes in cerebral hemodynamics

AU - Rogers, M. C.

AU - Traystman, R. J.

PY - 1979

Y1 - 1979

N2 - In dogs both nitroglycerin and nitroprusside are capable of elevating cerebral spinal fluid presssure (Pcsf), lowering cerebral perfusion pressure, and decreasing CBF. The increase in Pcsf appears to be independent of changes in CBF since marked increases in Pcsf occurred with no changes in CBF in the normal Pcsf group. This suggests the possibility that these drugs may increase cerebral blood volume and Pcsf via changes in cerebral venous capacitance. From a clinical perspective these studies confirm that both nitroglycerin and nitroprusside, in the presence of an initially elevated Pcsf, may lower cerebral blood flow. Since the patients most likely to receive these drugs often have marginal cerebral perfusion pressure to start, special attention must be paid to the cerebral hemodynamic effects of these agents. Finally, while producing less systemic hypotension, at any given dose range administered nitroglycerin appeared to elevate Pcsf more than did nitroprusside.

AB - In dogs both nitroglycerin and nitroprusside are capable of elevating cerebral spinal fluid presssure (Pcsf), lowering cerebral perfusion pressure, and decreasing CBF. The increase in Pcsf appears to be independent of changes in CBF since marked increases in Pcsf occurred with no changes in CBF in the normal Pcsf group. This suggests the possibility that these drugs may increase cerebral blood volume and Pcsf via changes in cerebral venous capacitance. From a clinical perspective these studies confirm that both nitroglycerin and nitroprusside, in the presence of an initially elevated Pcsf, may lower cerebral blood flow. Since the patients most likely to receive these drugs often have marginal cerebral perfusion pressure to start, special attention must be paid to the cerebral hemodynamic effects of these agents. Finally, while producing less systemic hypotension, at any given dose range administered nitroglycerin appeared to elevate Pcsf more than did nitroprusside.

UR - http://www.scopus.com/inward/record.url?scp=0018716761&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018716761&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0018716761

VL - 51

JO - Anesthesiology

JF - Anesthesiology

SN - 0003-3022

IS - 3 SUPPL

ER -