Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe

Benoit Driesschaert; Andrey A. Bobko; Valery V. Khramtsov; Jay L. Zweier

doi:10.1007/s12013-016-0732-y

Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe

Benoit Driesschaert, Andrey A. Bobko, Valery V. Khramtsov, Jay L. Zweier

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are known to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 × 10⁵ M⁻¹ s⁻¹ which is two order of magnitude higher than other TAMs, allowing high sensitivity measurement of superoxide.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Cell Biochemistry and Biophysics
DOIs	https://doi.org/10.1007/s12013-016-0732-y
State	Accepted/In press - May 20 2016
Externally published	Yes

Keywords

EPR
Oxygen
ROS
Superoxide
Trityl

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

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10.1007/s12013-016-0732-y

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abstract = "Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are known to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 × 105 M−1 s−1 which is two order of magnitude higher than other TAMs, allowing high sensitivity measurement of superoxide.",

keywords = "EPR, Oxygen, ROS, Superoxide, Trityl",

author = "Benoit Driesschaert and Bobko, {Andrey A.} and Khramtsov, {Valery V.} and Zweier, {Jay L.}",

year = "2016",

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doi = "10.1007/s12013-016-0732-y",

language = "English (US)",

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AU - Driesschaert, Benoit

AU - Bobko, Andrey A.

AU - Khramtsov, Valery V.

AU - Zweier, Jay L.

PY - 2016/5/20

Y1 - 2016/5/20

N2 - Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are known to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 × 105 M−1 s−1 which is two order of magnitude higher than other TAMs, allowing high sensitivity measurement of superoxide.

AB - Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are known to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 × 105 M−1 s−1 which is two order of magnitude higher than other TAMs, allowing high sensitivity measurement of superoxide.

KW - EPR

KW - Oxygen

KW - ROS

KW - Superoxide

KW - Trityl

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JO - Cell Biochemistry and Biophysics

JF - Cell Biochemistry and Biophysics

ER -

Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe

Abstract

Keywords

ASJC Scopus subject areas

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