Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe

Benoit Driesschaert, Andrey A. Bobko, Valery V. Khramtsov, Jay L. Zweier

Research output: Contribution to journalArticlepeer-review

Abstract

Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are known to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 × 105 M−1 s−1 which is two order of magnitude higher than other TAMs, allowing high sensitivity measurement of superoxide.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalCell Biochemistry and Biophysics
DOIs
StateAccepted/In press - May 20 2016
Externally publishedYes

Keywords

  • EPR
  • Oxygen
  • ROS
  • Superoxide
  • Trityl

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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