TY - JOUR
T1 - Nitric oxide synthase
T2 - Role as a transmitter/mediator in the brain and endocrine system
AU - Dawson, Ted M.
AU - Dawson, Valina L.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 1996
Y1 - 1996
N2 - Nitric oxide is a unique biological messenger molecule. It is produced by endothelial cells to mediate blood vessel relaxation; it mediates, in part, the immune functions of activated macrophages; and in the central and peripheral nervous system it serves as a neurotransmitter. In the nervous system, nitric oxide may regulate neurotransmitter release, it may play a key role in synaptic plasticity and morphogenesis, and it may regulate sexual and aggressive behavior. Under conditions of excessive formation, nitric oxide is emerging as an important neurotoxin.
AB - Nitric oxide is a unique biological messenger molecule. It is produced by endothelial cells to mediate blood vessel relaxation; it mediates, in part, the immune functions of activated macrophages; and in the central and peripheral nervous system it serves as a neurotransmitter. In the nervous system, nitric oxide may regulate neurotransmitter release, it may play a key role in synaptic plasticity and morphogenesis, and it may regulate sexual and aggressive behavior. Under conditions of excessive formation, nitric oxide is emerging as an important neurotoxin.
KW - Endothelium-derived relaxing factor
KW - Long-term potentiation
KW - NADPH diaphorase
KW - Neurotoxicity
KW - Poly-ADP-ribose synthetase
UR - http://www.scopus.com/inward/record.url?scp=0029873572&partnerID=8YFLogxK
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U2 - 10.1146/annurev.med.47.1.219
DO - 10.1146/annurev.med.47.1.219
M3 - Review article
C2 - 8712777
AN - SCOPUS:0029873572
SN - 0066-4219
VL - 47
SP - 219
EP - 227
JO - Annual review of medicine
JF - Annual review of medicine
ER -