Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

David S. Bredt, Charles E. Glatt, Paul M. Hwang, Majid Fotuhi, Ted M. Dawson, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

Nitric oxide is a free radical that has been recently recognized as a neural messenger molecule. Nitric oxide synthase has now been purified and molecularly cloned from brain. Using specific antibodies and oligonucleotide probes, we have localized brain nitric oxide synthase to discrete neuronal populations in the rat and primate brain. Nitric oxide synthase is exclusively neuronal, and its localization is absolutely coincident with NADPH diaphorase staining in both rat and primate.

Original languageEnglish (US)
Pages (from-to)615-624
Number of pages10
JournalNeuron
Volume7
Issue number4
DOIs
StatePublished - Oct 1991

ASJC Scopus subject areas

  • Neuroscience(all)

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