Nitric oxide synthase (NOS) inhibitors ameliorate retinal damage induced by ischemia in rats

Tim T. Lam, Mark O M Tso

Research output: Contribution to journalArticle

Abstract

The dose effects of two nitric oxide synthase (NOS) inhibitors: N(G)- nitro-L-arginine (L-NNA) and N(ω)-monomethyl-L-arginine (L-NMMA), were evaluated in an established rat model of retinal ischemia using morphometry of the inner retina: inner retinal thickness (IRT) measurements and retinal ganglion cell counts (RGCCs) of the posterior and peripheral retina. By IRT and RGCCs of the posterior retina, there were dose dependent beneficial effects of both inhibitors. However, by RGCCs of the peripheral retina, there was no significant beneficial effect by either inhibitor. In addition, L- NMMA at 0.3 mg/kg aggravated the loss of ROE in both the posterior and peripheral retina. An important role and a possible differential site of action of NOS in the pathophysiology of retinal ischemia are implicated.

Original languageEnglish (US)
Pages (from-to)329-340
Number of pages12
JournalResearch Communications in Molecular Pathology and Pharmacology
Volume92
Issue number3
StatePublished - 1996
Externally publishedYes

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Nitric Oxide Synthase
Retina
Ischemia
Retinal Ganglion Cells
omega-N-Methylarginine
Cell Count
Arginine

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pathology and Forensic Medicine

Cite this

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abstract = "The dose effects of two nitric oxide synthase (NOS) inhibitors: N(G)- nitro-L-arginine (L-NNA) and N(ω)-monomethyl-L-arginine (L-NMMA), were evaluated in an established rat model of retinal ischemia using morphometry of the inner retina: inner retinal thickness (IRT) measurements and retinal ganglion cell counts (RGCCs) of the posterior and peripheral retina. By IRT and RGCCs of the posterior retina, there were dose dependent beneficial effects of both inhibitors. However, by RGCCs of the peripheral retina, there was no significant beneficial effect by either inhibitor. In addition, L- NMMA at 0.3 mg/kg aggravated the loss of ROE in both the posterior and peripheral retina. An important role and a possible differential site of action of NOS in the pathophysiology of retinal ischemia are implicated.",
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