Abstract
The dose effects of two nitric oxide synthase (NOS) inhibitors: N(G)- nitro-L-arginine (L-NNA) and N(ω)-monomethyl-L-arginine (L-NMMA), were evaluated in an established rat model of retinal ischemia using morphometry of the inner retina: inner retinal thickness (IRT) measurements and retinal ganglion cell counts (RGCCs) of the posterior and peripheral retina. By IRT and RGCCs of the posterior retina, there were dose dependent beneficial effects of both inhibitors. However, by RGCCs of the peripheral retina, there was no significant beneficial effect by either inhibitor. In addition, L- NMMA at 0.3 mg/kg aggravated the loss of ROE in both the posterior and peripheral retina. An important role and a possible differential site of action of NOS in the pathophysiology of retinal ischemia are implicated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 329-340 |
| Number of pages | 12 |
| Journal | Research Communications in Molecular Pathology and Pharmacology |
| Volume | 92 |
| Issue number | 3 |
| State | Published - 1996 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pathology and Forensic Medicine
Cite this
Nitric oxide synthase (NOS) inhibitors ameliorate retinal damage induced by ischemia in rats. / Lam, Tim T.; Tso, Mark O M.
In: Research Communications in Molecular Pathology and Pharmacology, Vol. 92, No. 3, 1996, p. 329-340.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nitric oxide synthase (NOS) inhibitors ameliorate retinal damage induced by ischemia in rats
AU - Lam, Tim T.
AU - Tso, Mark O M
PY - 1996
Y1 - 1996
N2 - The dose effects of two nitric oxide synthase (NOS) inhibitors: N(G)- nitro-L-arginine (L-NNA) and N(ω)-monomethyl-L-arginine (L-NMMA), were evaluated in an established rat model of retinal ischemia using morphometry of the inner retina: inner retinal thickness (IRT) measurements and retinal ganglion cell counts (RGCCs) of the posterior and peripheral retina. By IRT and RGCCs of the posterior retina, there were dose dependent beneficial effects of both inhibitors. However, by RGCCs of the peripheral retina, there was no significant beneficial effect by either inhibitor. In addition, L- NMMA at 0.3 mg/kg aggravated the loss of ROE in both the posterior and peripheral retina. An important role and a possible differential site of action of NOS in the pathophysiology of retinal ischemia are implicated.
AB - The dose effects of two nitric oxide synthase (NOS) inhibitors: N(G)- nitro-L-arginine (L-NNA) and N(ω)-monomethyl-L-arginine (L-NMMA), were evaluated in an established rat model of retinal ischemia using morphometry of the inner retina: inner retinal thickness (IRT) measurements and retinal ganglion cell counts (RGCCs) of the posterior and peripheral retina. By IRT and RGCCs of the posterior retina, there were dose dependent beneficial effects of both inhibitors. However, by RGCCs of the peripheral retina, there was no significant beneficial effect by either inhibitor. In addition, L- NMMA at 0.3 mg/kg aggravated the loss of ROE in both the posterior and peripheral retina. An important role and a possible differential site of action of NOS in the pathophysiology of retinal ischemia are implicated.
UR - http://www.scopus.com/inward/record.url?scp=0029951139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029951139&partnerID=8YFLogxK
M3 - Article
VL - 92
SP - 329
EP - 340
JO - Research Communications in Molecular Pathology and Pharmacology
JF - Research Communications in Molecular Pathology and Pharmacology
SN - 0034-5164
IS - 3
ER -