Nitric oxide signaling and the regulation of myocardial function

Mark T. Ziolo, Mark Kohr, Honglan Wang

Research output: Contribution to journalArticle

Abstract

Nitric oxide, which is produced endogenously within cardiac myocytes by three distinct isoforms of nitric oxide synthase, is a key regulator of myocardial function. This review will focus on the regulation of myocardial function by each nitric oxide synthase isoform during health and disease, with a specific emphasis on the proposed end-targets and signaling pathways.

Original languageEnglish (US)
Pages (from-to)625-632
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume45
Issue number5
DOIs
StatePublished - Nov 2008
Externally publishedYes

Fingerprint

Nitric Oxide Synthase
Nitric Oxide
Protein Isoforms
Cardiac Myocytes
Health

Keywords

  • cGMP
  • Excitation-contraction coupling
  • l-type Ca channel
  • NOS
  • Peroxynitrite
  • Phospholamban
  • Ryanodine receptor

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Nitric oxide signaling and the regulation of myocardial function. / Ziolo, Mark T.; Kohr, Mark; Wang, Honglan.

In: Journal of Molecular and Cellular Cardiology, Vol. 45, No. 5, 11.2008, p. 625-632.

Research output: Contribution to journalArticle

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