NITRIC OXIDE: ROLE IN NEUROTOXICITY

Research output: Contribution to journalArticle

Abstract

1. Nitric oxide (NO) is a novel neuronal messenger molecule which interacts with surrounding neurones, not by synaptic transmission but by diffusion between cells. 2. No is produced following stimulation of the enzyme, NO synthase (NOS). After synthesis, NO exerts its biological actions by diffusion to the site of action. Therefore, the way to regulate the physiological actions of NO is to regulate NOS. 3. NOS is activated by the influx of calcium from glutamate‐activated N‐methyl‐D‐aspartate receptors. Overactivation of these receptors leads to overproduction of NO and neuronal cell death. 4. NOS can be regulated at the catalytic site, at the flavoproteins, at the calmodulin site and by phosphorylation. 5. In excess, NO is toxic to neurones. This toxicity is mediated largely by an interaction with the superoxide anion, presumably through the generation of the oxidant, peroxynitrite. 6. NO or peroxynitrite‐mediated neuronal injury involves the activation of the nuclear protein, poly(ADP‐ribose)synthetase.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume22
Issue number4
DOIs
StatePublished - Apr 1995

Keywords

  • N‐methyl‐D‐aspartate receptor
  • glutamate
  • neurotoxicity
  • nitric oxide
  • peroxynitrite
  • poly(ADP‐ribose)synthetase
  • superoxide anion.

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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