Nitric oxide-generating hydrogels inhibit neointima formation

Kristyn S. Bohl Masters, Elizabeth A. Lipke, Elizabeth E. Rice, Meghan S. Liel, Heather A. Myler, Corinna Zygourakis, David A. Tulis, Jennifer L. West

Research output: Contribution to journalArticle

Abstract

This study evaluated the effects of localized delivery of nitric oxide (NO) from hydrogels covalently modified with S-nitrosocysteine (Cys-NO) on neoinitma formation, a key component of restenosis, in a rat balloon-injury model. Soluble Cys-NO was used in preliminary studies to identify dosage ranges that were able to simultaneously inhibit smooth muscle cell proliferation, enhance endothelial cell proliferation, and reduce platelet adhesion. Photo-cross-linked PEG-based hydrogels were formed with covalently immobilized Cys-NO. These materials release NO for approximately 24 h and can be applied to tissues and photo-cross-linked in situ to form local drug-delivery systems. Localized delivery of NO from hydrogels containing Cys-NO inhibited neointima formation in a rat balloon-injury model by approximately 75% at 14 days.

Original languageEnglish (US)
Pages (from-to)659-672
Number of pages14
JournalJournal of Biomaterials Science, Polymer Edition
Volume16
Issue number5
DOIs
StatePublished - May 1 2005
Externally publishedYes

Fingerprint

Neointima
Hydrogels
Nitric oxide
Nitric Oxide
Balloons
Cell proliferation
Rats
Endothelial cells
Cell Proliferation
Platelets
Polyethylene glycols
Muscle
Wounds and Injuries
Drug Delivery Systems
Adhesion
Tissue
Smooth Muscle Myocytes
Blood Platelets
Endothelial Cells
S-nitrosocysteine

Keywords

  • Drug delivery
  • Hydrogel
  • Nitric oxide
  • Restenosis
  • S-nitrosocysteine
  • Thrombosis

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials

Cite this

Bohl Masters, K. S., Lipke, E. A., Rice, E. E., Liel, M. S., Myler, H. A., Zygourakis, C., ... West, J. L. (2005). Nitric oxide-generating hydrogels inhibit neointima formation. Journal of Biomaterials Science, Polymer Edition, 16(5), 659-672. https://doi.org/10.1163/1568562053783722

Nitric oxide-generating hydrogels inhibit neointima formation. / Bohl Masters, Kristyn S.; Lipke, Elizabeth A.; Rice, Elizabeth E.; Liel, Meghan S.; Myler, Heather A.; Zygourakis, Corinna; Tulis, David A.; West, Jennifer L.

In: Journal of Biomaterials Science, Polymer Edition, Vol. 16, No. 5, 01.05.2005, p. 659-672.

Research output: Contribution to journalArticle

Bohl Masters, KS, Lipke, EA, Rice, EE, Liel, MS, Myler, HA, Zygourakis, C, Tulis, DA & West, JL 2005, 'Nitric oxide-generating hydrogels inhibit neointima formation', Journal of Biomaterials Science, Polymer Edition, vol. 16, no. 5, pp. 659-672. https://doi.org/10.1163/1568562053783722
Bohl Masters KS, Lipke EA, Rice EE, Liel MS, Myler HA, Zygourakis C et al. Nitric oxide-generating hydrogels inhibit neointima formation. Journal of Biomaterials Science, Polymer Edition. 2005 May 1;16(5):659-672. https://doi.org/10.1163/1568562053783722
Bohl Masters, Kristyn S. ; Lipke, Elizabeth A. ; Rice, Elizabeth E. ; Liel, Meghan S. ; Myler, Heather A. ; Zygourakis, Corinna ; Tulis, David A. ; West, Jennifer L. / Nitric oxide-generating hydrogels inhibit neointima formation. In: Journal of Biomaterials Science, Polymer Edition. 2005 ; Vol. 16, No. 5. pp. 659-672.
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