Nitric oxide-generating hydrogels inhibit neointima formation

Kristyn S. Bohl Masters; Elizabeth A. Lipke; Elizabeth E. Rice; Meghan S. Liel; Heather A. Myler; Corinna Zygourakis; David A. Tulis; Jennifer L. West

doi:10.1163/1568562053783722

Nitric oxide-generating hydrogels inhibit neointima formation

Kristyn S. Bohl Masters, Elizabeth A. Lipke, Elizabeth E. Rice, Meghan S. Liel, Heather A. Myler, Corinna Zygourakis, David A. Tulis, Jennifer L. West

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

This study evaluated the effects of localized delivery of nitric oxide (NO) from hydrogels covalently modified with S-nitrosocysteine (Cys-NO) on neoinitma formation, a key component of restenosis, in a rat balloon-injury model. Soluble Cys-NO was used in preliminary studies to identify dosage ranges that were able to simultaneously inhibit smooth muscle cell proliferation, enhance endothelial cell proliferation, and reduce platelet adhesion. Photo-cross-linked PEG-based hydrogels were formed with covalently immobilized Cys-NO. These materials release NO for approximately 24 h and can be applied to tissues and photo-cross-linked in situ to form local drug-delivery systems. Localized delivery of NO from hydrogels containing Cys-NO inhibited neointima formation in a rat balloon-injury model by approximately 75% at 14 days.

Original language	English (US)
Pages (from-to)	659-672
Number of pages	14
Journal	Journal of Biomaterials Science, Polymer Edition
Volume	16
Issue number	5
DOIs	https://doi.org/10.1163/1568562053783722
State	Published - May 2005
Externally published	Yes

Keywords

Drug delivery
Hydrogel
Nitric oxide
Restenosis
S-nitrosocysteine
Thrombosis

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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10.1163/1568562053783722

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title = "Nitric oxide-generating hydrogels inhibit neointima formation",

abstract = "This study evaluated the effects of localized delivery of nitric oxide (NO) from hydrogels covalently modified with S-nitrosocysteine (Cys-NO) on neoinitma formation, a key component of restenosis, in a rat balloon-injury model. Soluble Cys-NO was used in preliminary studies to identify dosage ranges that were able to simultaneously inhibit smooth muscle cell proliferation, enhance endothelial cell proliferation, and reduce platelet adhesion. Photo-cross-linked PEG-based hydrogels were formed with covalently immobilized Cys-NO. These materials release NO for approximately 24 h and can be applied to tissues and photo-cross-linked in situ to form local drug-delivery systems. Localized delivery of NO from hydrogels containing Cys-NO inhibited neointima formation in a rat balloon-injury model by approximately 75% at 14 days.",

keywords = "Drug delivery, Hydrogel, Nitric oxide, Restenosis, S-nitrosocysteine, Thrombosis",

author = "{Bohl Masters}, {Kristyn S.} and Lipke, {Elizabeth A.} and Rice, {Elizabeth E.} and Liel, {Meghan S.} and Myler, {Heather A.} and Corinna Zygourakis and Tulis, {David A.} and West, {Jennifer L.}",

year = "2005",

month = may,

doi = "10.1163/1568562053783722",

language = "English (US)",

volume = "16",

pages = "659--672",

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T1 - Nitric oxide-generating hydrogels inhibit neointima formation

AU - Bohl Masters, Kristyn S.

AU - Lipke, Elizabeth A.

AU - Rice, Elizabeth E.

AU - Liel, Meghan S.

AU - Myler, Heather A.

AU - Zygourakis, Corinna

AU - Tulis, David A.

AU - West, Jennifer L.

PY - 2005/5

Y1 - 2005/5

N2 - This study evaluated the effects of localized delivery of nitric oxide (NO) from hydrogels covalently modified with S-nitrosocysteine (Cys-NO) on neoinitma formation, a key component of restenosis, in a rat balloon-injury model. Soluble Cys-NO was used in preliminary studies to identify dosage ranges that were able to simultaneously inhibit smooth muscle cell proliferation, enhance endothelial cell proliferation, and reduce platelet adhesion. Photo-cross-linked PEG-based hydrogels were formed with covalently immobilized Cys-NO. These materials release NO for approximately 24 h and can be applied to tissues and photo-cross-linked in situ to form local drug-delivery systems. Localized delivery of NO from hydrogels containing Cys-NO inhibited neointima formation in a rat balloon-injury model by approximately 75% at 14 days.

AB - This study evaluated the effects of localized delivery of nitric oxide (NO) from hydrogels covalently modified with S-nitrosocysteine (Cys-NO) on neoinitma formation, a key component of restenosis, in a rat balloon-injury model. Soluble Cys-NO was used in preliminary studies to identify dosage ranges that were able to simultaneously inhibit smooth muscle cell proliferation, enhance endothelial cell proliferation, and reduce platelet adhesion. Photo-cross-linked PEG-based hydrogels were formed with covalently immobilized Cys-NO. These materials release NO for approximately 24 h and can be applied to tissues and photo-cross-linked in situ to form local drug-delivery systems. Localized delivery of NO from hydrogels containing Cys-NO inhibited neointima formation in a rat balloon-injury model by approximately 75% at 14 days.

KW - Drug delivery

KW - Hydrogel

KW - Nitric oxide

KW - Restenosis

KW - S-nitrosocysteine

KW - Thrombosis

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SN - 0920-5063

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JO - Journal of Biomaterials Science, Polymer Edition

JF - Journal of Biomaterials Science, Polymer Edition

IS - 5

ER -

Nitric oxide-generating hydrogels inhibit neointima formation

Abstract

Keywords

ASJC Scopus subject areas

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