Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism

Hitoshi Takano, Xian Liang Tang, Yumin Qiu, Yiru Guo, Brent A. French, Roberto Bolli

Research output: Contribution to journalArticle

Abstract

The goal of this study was to test the hypothesis that the cardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked by treatment with NO donors. In phase I (studies of myocardial stunning), conscious rabbits underwent a sequence of six 4-minute coronary occlusion/4-minute reperfusion cycles for 3 consecutive days (days 1, 2, and 3). In group I (controls, n=6), the total deficit of systolic wall thickening (WTh) after the sixth reperfusion was reduced by 54% on days 2 and 3 compared with day 1 (P-1 · min-1 IV for 75 minutes [group III, n=5]) 24 hours before the first sequence of occlusion/reperfusion cycles, the deficit of WTh on day 1 was 60% (group II) and 54% (group III) less than that observed in controls (P- and ·OH scavenger mercaptopropionyl glycine (MPG) (group IV, n=5). In phase II (studies of myocardial infarction), conscious rabbits underwent a 30- minute coronary occlusion followed by 3 days of reperfusion. When rabbits were preconditioned 24 hours earlier with six 4-minute occlusion/4-minute reperfusion cycles, infarct size was reduced by 43% (33.2 ± 2.7% versus 58.3 ± 4.1% of the region at risk in controls, P- and/or ·OH. Since a relatively brief treatment with hemodynamically inactive doses of NO donors can induce long-lasting protective effects, these agents could be useful for preconditioning the heart in patients.

Original languageEnglish (US)
Pages (from-to)73-84
Number of pages12
JournalCirculation Research
Volume83
Issue number1
StatePublished - Jul 13 1998
Externally publishedYes

Fingerprint

Myocardial Stunning
Nitric Oxide Donors
Reperfusion
Antioxidants
Myocardial Infarction
Rabbits
Coronary Occlusion
Protective Agents
Ischemic Preconditioning
Glycine
Control Groups
Therapeutics

Keywords

  • Diethylenetriamine/nitric oxide
  • Myocardial ischemia
  • Myocardial reperfusion
  • S-nitroso-N-acetylpenicillamine

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism. / Takano, Hitoshi; Tang, Xian Liang; Qiu, Yumin; Guo, Yiru; French, Brent A.; Bolli, Roberto.

In: Circulation Research, Vol. 83, No. 1, 13.07.1998, p. 73-84.

Research output: Contribution to journalArticle

Takano, Hitoshi ; Tang, Xian Liang ; Qiu, Yumin ; Guo, Yiru ; French, Brent A. ; Bolli, Roberto. / Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism. In: Circulation Research. 1998 ; Vol. 83, No. 1. pp. 73-84.
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