Nitric oxide accounts for dose-dependent estrogen-mediated coronary relaxation after acute estrogen withdrawal

Peter Collins, Joanne Shay, Canwen Jiang, Jonathan Moss

Research output: Contribution to journalArticle

Abstract

Background: Estrogen replacement therapy reduces the risk of coronary heart disease in postmenopausal women, and estrogen treatment modulates endothelium-dependent vasodilation in ovariectomized, atherosclerotic monkeys. Estradiol-17β also induces relaxation in isolated rabbit coronary arteries as well as cerebral basilar arteries. The estrogen concentrations required to induce such relaxation are in the pharmacological range (10-6 to 10-5 mol/L). Methods and Results: The present study was designed to test whether the sensitivity and specificity of the relaxing response of coronary vascular smooth muscle to exogenous estradiol-17β is dependent on the sex hormone status of the animal. In coronary artery rings contracted with PGF(2α) (3x10-5 mol/L), estradiol-17β caused significant relaxation at a physiological estrogen concentration (10-9 mol/L), in coronary artery rings from oophorectomized, estrogen-treated and acutely estrogen-withdrawn rabbits only. Relaxation induced by estradiol-17β at lower concentrations (10-9 to 10-6 mol/L) in these rings was 20±6%, 42±8%, 54±9%, and 75±8%, respectively, compared with 4±2%, 12±5%, 16±7%, and 25±12% and 5±2%, 12±5%, 18±8%, and 23±10% in rings from estrogen-maintained and oophorectomized rabbits, respectively (P

Original languageEnglish (US)
Pages (from-to)1964-1968
Number of pages5
JournalCirculation
Volume90
Issue number4 I
StatePublished - Oct 1994
Externally publishedYes

Fingerprint

Nitric Oxide
Estrogens
Estradiol
Coronary Vessels
Rabbits
Basilar Artery
Estrogen Replacement Therapy
Cerebral Arteries
Gonadal Steroid Hormones
Prostaglandins F
Vascular Smooth Muscle
Vasodilation
Endothelium
Haplorhini
Coronary Disease
Pharmacology
Sensitivity and Specificity
Therapeutics

Keywords

  • estrogen
  • nitric oxide
  • smooth muscle

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Nitric oxide accounts for dose-dependent estrogen-mediated coronary relaxation after acute estrogen withdrawal. / Collins, Peter; Shay, Joanne; Jiang, Canwen; Moss, Jonathan.

In: Circulation, Vol. 90, No. 4 I, 10.1994, p. 1964-1968.

Research output: Contribution to journalArticle

Collins, Peter ; Shay, Joanne ; Jiang, Canwen ; Moss, Jonathan. / Nitric oxide accounts for dose-dependent estrogen-mediated coronary relaxation after acute estrogen withdrawal. In: Circulation. 1994 ; Vol. 90, No. 4 I. pp. 1964-1968.
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