Nitric oxide: A physiologic mediator of penile erection

Arthur Burnett, Charles J. Lowenstein, David S. Bredt, Thomas S K Chang, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Nitric oxide (NO) is a cytotoxic agent of macrophages, a messenger molecule of neurons, and a vasodilator produced by endothelial cells. NO synthase, the synthetic enzyme for NO, was localized to rat penile neurons innervating the corpora cavernosa and to neuronal plexuses in the adventitial layer of penile arteries. Small doses of NO synthase inhibitors abolished electrophysiologically induced penile erections. These results establish NO as a physiologic mediator of erectile function.

Original languageEnglish (US)
Pages (from-to)401-403
Number of pages3
JournalScience
Volume257
Issue number5068
StatePublished - 1992

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Penile Erection
Nitric Oxide
Nitric Oxide Synthase
Neurons
Adventitia
Cytotoxins
Vasodilator Agents
Endothelial Cells
Arteries
Macrophages
Enzymes

ASJC Scopus subject areas

  • General

Cite this

Burnett, A., Lowenstein, C. J., Bredt, D. S., Chang, T. S. K., & Snyder, S. H. (1992). Nitric oxide: A physiologic mediator of penile erection. Science, 257(5068), 401-403.

Nitric oxide : A physiologic mediator of penile erection. / Burnett, Arthur; Lowenstein, Charles J.; Bredt, David S.; Chang, Thomas S K; Snyder, Solomon H.

In: Science, Vol. 257, No. 5068, 1992, p. 401-403.

Research output: Contribution to journalArticle

Burnett, A, Lowenstein, CJ, Bredt, DS, Chang, TSK & Snyder, SH 1992, 'Nitric oxide: A physiologic mediator of penile erection', Science, vol. 257, no. 5068, pp. 401-403.
Burnett A, Lowenstein CJ, Bredt DS, Chang TSK, Snyder SH. Nitric oxide: A physiologic mediator of penile erection. Science. 1992;257(5068):401-403.
Burnett, Arthur ; Lowenstein, Charles J. ; Bredt, David S. ; Chang, Thomas S K ; Snyder, Solomon H. / Nitric oxide : A physiologic mediator of penile erection. In: Science. 1992 ; Vol. 257, No. 5068. pp. 401-403.
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