Nitric oxide: A neural messenger

Samie R. Jaffrey; Solomon H. Snyder

doi:10.1146/annurev.cb.11.110195.002221

Nitric oxide: A neural messenger

Samie R. Jaffrey, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Review article › peer-review

292 Scopus citations

Abstract

Nitric oxide (NO) is a messenger molecule that is now a well established neurotransmitter in the central and peripheral nervous systems. NO was initally characterized as the 'endothelium-derived relaxation factor' and subsequently found to mediate the elevation in cGMP following glutamatergic stimulation in the nervous system. Pharmacological and immunohistochemical data suggest numerous roles for NO throughout the body. NO knockout mice have demonstrated that NO is essential in behavioral and autonomic function. NO also appears to have neurotoxic and neuroprotective effects and may have a role in the pathogenesis of stroke and other neurodegenerative disorders.

Original language	English (US)
Pages (from-to)	417-440
Number of pages	24
Journal	Annual Review of Cell and Developmental Biology
Volume	11
DOIs	https://doi.org/10.1146/annurev.cb.11.110195.002221
State	Published - 1995

Keywords

carbon monoxide
cyclic GMP
glutamate
neurotoxicity

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1146/annurev.cb.11.110195.002221

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abstract = "Nitric oxide (NO) is a messenger molecule that is now a well established neurotransmitter in the central and peripheral nervous systems. NO was initally characterized as the 'endothelium-derived relaxation factor' and subsequently found to mediate the elevation in cGMP following glutamatergic stimulation in the nervous system. Pharmacological and immunohistochemical data suggest numerous roles for NO throughout the body. NO knockout mice have demonstrated that NO is essential in behavioral and autonomic function. NO also appears to have neurotoxic and neuroprotective effects and may have a role in the pathogenesis of stroke and other neurodegenerative disorders.",

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AB - Nitric oxide (NO) is a messenger molecule that is now a well established neurotransmitter in the central and peripheral nervous systems. NO was initally characterized as the 'endothelium-derived relaxation factor' and subsequently found to mediate the elevation in cGMP following glutamatergic stimulation in the nervous system. Pharmacological and immunohistochemical data suggest numerous roles for NO throughout the body. NO knockout mice have demonstrated that NO is essential in behavioral and autonomic function. NO also appears to have neurotoxic and neuroprotective effects and may have a role in the pathogenesis of stroke and other neurodegenerative disorders.

KW - carbon monoxide

KW - cyclic GMP

KW - glutamate

KW - neurotoxicity

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Nitric oxide: A neural messenger

Abstract

Keywords

ASJC Scopus subject areas

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