Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats

Seva G. Khambadkone, Zachary A. Cordner, Faith Dickerson, Emily G Severance, Emese Prandovszky, Mikhail Pletnikov, Jian-Chun Xiao, Ye Li, Gretha J. Boersma, C. Conover Talbot, Wayne W. Campbell, Christian S. Wright, C. Evan Siple, Timothy H Moran, Kellie Tamashiro, Robert H Yolken

Research output: Contribution to journalArticle

Abstract

Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating nitrated dry cured meat but not other meat or fish products was strongly and independently associated with current mania (adjusted odds ratio 3.49, 95% confidence interval (CI) 2.24–5.45, p < 8.97 × 10−8). Lower odds of association were found between eating nitrated dry cured meat and other psychiatric disorders. We further found that the feeding of meat preparations with added nitrate to rats resulted in hyperactivity reminiscent of human mania, alterations in brain pathways that have been implicated in human bipolar disorder, and changes in intestinal microbiota. These findings may lead to new methods for preventing mania and for developing novel therapeutic interventions.

Original languageEnglish (US)
JournalMolecular Psychiatry
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Meat Products
Bipolar Disorder
Gene Expression
Brain
Meat
Psychiatry
Eating
Fish Products
Environmental Exposure
Nitrates
Odds Ratio
Confidence Intervals
Morbidity
Mortality

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats. / Khambadkone, Seva G.; Cordner, Zachary A.; Dickerson, Faith; Severance, Emily G; Prandovszky, Emese; Pletnikov, Mikhail; Xiao, Jian-Chun; Li, Ye; Boersma, Gretha J.; Talbot, C. Conover; Campbell, Wayne W.; Wright, Christian S.; Siple, C. Evan; Moran, Timothy H; Tamashiro, Kellie; Yolken, Robert H.

In: Molecular Psychiatry, 01.01.2018.

Research output: Contribution to journalArticle

Khambadkone, Seva G. ; Cordner, Zachary A. ; Dickerson, Faith ; Severance, Emily G ; Prandovszky, Emese ; Pletnikov, Mikhail ; Xiao, Jian-Chun ; Li, Ye ; Boersma, Gretha J. ; Talbot, C. Conover ; Campbell, Wayne W. ; Wright, Christian S. ; Siple, C. Evan ; Moran, Timothy H ; Tamashiro, Kellie ; Yolken, Robert H. / Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats. In: Molecular Psychiatry. 2018.
@article{491d80765a3a4f6192d0edc490962a7c,
title = "Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats",
abstract = "Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating nitrated dry cured meat but not other meat or fish products was strongly and independently associated with current mania (adjusted odds ratio 3.49, 95{\%} confidence interval (CI) 2.24–5.45, p < 8.97 × 10−8). Lower odds of association were found between eating nitrated dry cured meat and other psychiatric disorders. We further found that the feeding of meat preparations with added nitrate to rats resulted in hyperactivity reminiscent of human mania, alterations in brain pathways that have been implicated in human bipolar disorder, and changes in intestinal microbiota. These findings may lead to new methods for preventing mania and for developing novel therapeutic interventions.",
author = "Khambadkone, {Seva G.} and Cordner, {Zachary A.} and Faith Dickerson and Severance, {Emily G} and Emese Prandovszky and Mikhail Pletnikov and Jian-Chun Xiao and Ye Li and Boersma, {Gretha J.} and Talbot, {C. Conover} and Campbell, {Wayne W.} and Wright, {Christian S.} and Siple, {C. Evan} and Moran, {Timothy H} and Kellie Tamashiro and Yolken, {Robert H}",
year = "2018",
month = "1",
day = "1",
doi = "10.1038/s41380-018-0105-6",
language = "English (US)",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats

AU - Khambadkone, Seva G.

AU - Cordner, Zachary A.

AU - Dickerson, Faith

AU - Severance, Emily G

AU - Prandovszky, Emese

AU - Pletnikov, Mikhail

AU - Xiao, Jian-Chun

AU - Li, Ye

AU - Boersma, Gretha J.

AU - Talbot, C. Conover

AU - Campbell, Wayne W.

AU - Wright, Christian S.

AU - Siple, C. Evan

AU - Moran, Timothy H

AU - Tamashiro, Kellie

AU - Yolken, Robert H

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating nitrated dry cured meat but not other meat or fish products was strongly and independently associated with current mania (adjusted odds ratio 3.49, 95% confidence interval (CI) 2.24–5.45, p < 8.97 × 10−8). Lower odds of association were found between eating nitrated dry cured meat and other psychiatric disorders. We further found that the feeding of meat preparations with added nitrate to rats resulted in hyperactivity reminiscent of human mania, alterations in brain pathways that have been implicated in human bipolar disorder, and changes in intestinal microbiota. These findings may lead to new methods for preventing mania and for developing novel therapeutic interventions.

AB - Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating nitrated dry cured meat but not other meat or fish products was strongly and independently associated with current mania (adjusted odds ratio 3.49, 95% confidence interval (CI) 2.24–5.45, p < 8.97 × 10−8). Lower odds of association were found between eating nitrated dry cured meat and other psychiatric disorders. We further found that the feeding of meat preparations with added nitrate to rats resulted in hyperactivity reminiscent of human mania, alterations in brain pathways that have been implicated in human bipolar disorder, and changes in intestinal microbiota. These findings may lead to new methods for preventing mania and for developing novel therapeutic interventions.

UR - http://www.scopus.com/inward/record.url?scp=85050124075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050124075&partnerID=8YFLogxK

U2 - 10.1038/s41380-018-0105-6

DO - 10.1038/s41380-018-0105-6

M3 - Article

C2 - 30022042

AN - SCOPUS:85050124075

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

ER -