Nitrate and nitrite in biology, nutrition and therapeutics

Jon O. Lundberg, Mark T. Gladwin, Amrita Ahluwalia, Nigel Benjamin, Nathan S. Bryan, Anthony Butler, Pedro Cabrales, Angela Fago, Martin Feelisch, Peter C. Ford, Bruce A. Freeman, Michael Frenneaux, Joel Friedman, Malte Kelm, Christopher G. Kevil, Daniel B. Kim-Shapiro, Andrey V. Kozlov, Jack R. Lancaster, David J. Lefer, Kenneth McCollKenneth McCurry, Rakesh P. Patel, Joel Petersson, Tienush Rassaf, Valentin P. Reutov, George B. Richter-Addo, Alan Schechter, Sruti Shiva, Koichiro Tsuchiya, Ernst E. Van Faassen, Andrew J. Webb, Brian S. Zuckerbraun, Jay L. Zweier, Eddie Weitzberg

Research output: Contribution to journalArticle

Abstract

Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.

Original languageEnglish (US)
Pages (from-to)865-869
Number of pages5
JournalNature Chemical Biology
Volume5
Issue number12
DOIs
StatePublished - Dec 2009
Externally publishedYes

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Nitrites
Nitrates
Nitric Oxide
Nitrogen Oxides
Biochemistry
Therapeutics

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Lundberg, J. O., Gladwin, M. T., Ahluwalia, A., Benjamin, N., Bryan, N. S., Butler, A., ... Weitzberg, E. (2009). Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology, 5(12), 865-869. https://doi.org/10.1038/nchembio.260

Nitrate and nitrite in biology, nutrition and therapeutics. / Lundberg, Jon O.; Gladwin, Mark T.; Ahluwalia, Amrita; Benjamin, Nigel; Bryan, Nathan S.; Butler, Anthony; Cabrales, Pedro; Fago, Angela; Feelisch, Martin; Ford, Peter C.; Freeman, Bruce A.; Frenneaux, Michael; Friedman, Joel; Kelm, Malte; Kevil, Christopher G.; Kim-Shapiro, Daniel B.; Kozlov, Andrey V.; Lancaster, Jack R.; Lefer, David J.; McColl, Kenneth; McCurry, Kenneth; Patel, Rakesh P.; Petersson, Joel; Rassaf, Tienush; Reutov, Valentin P.; Richter-Addo, George B.; Schechter, Alan; Shiva, Sruti; Tsuchiya, Koichiro; Van Faassen, Ernst E.; Webb, Andrew J.; Zuckerbraun, Brian S.; Zweier, Jay L.; Weitzberg, Eddie.

In: Nature Chemical Biology, Vol. 5, No. 12, 12.2009, p. 865-869.

Research output: Contribution to journalArticle

Lundberg, JO, Gladwin, MT, Ahluwalia, A, Benjamin, N, Bryan, NS, Butler, A, Cabrales, P, Fago, A, Feelisch, M, Ford, PC, Freeman, BA, Frenneaux, M, Friedman, J, Kelm, M, Kevil, CG, Kim-Shapiro, DB, Kozlov, AV, Lancaster, JR, Lefer, DJ, McColl, K, McCurry, K, Patel, RP, Petersson, J, Rassaf, T, Reutov, VP, Richter-Addo, GB, Schechter, A, Shiva, S, Tsuchiya, K, Van Faassen, EE, Webb, AJ, Zuckerbraun, BS, Zweier, JL & Weitzberg, E 2009, 'Nitrate and nitrite in biology, nutrition and therapeutics', Nature Chemical Biology, vol. 5, no. 12, pp. 865-869. https://doi.org/10.1038/nchembio.260
Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A et al. Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology. 2009 Dec;5(12):865-869. https://doi.org/10.1038/nchembio.260
Lundberg, Jon O. ; Gladwin, Mark T. ; Ahluwalia, Amrita ; Benjamin, Nigel ; Bryan, Nathan S. ; Butler, Anthony ; Cabrales, Pedro ; Fago, Angela ; Feelisch, Martin ; Ford, Peter C. ; Freeman, Bruce A. ; Frenneaux, Michael ; Friedman, Joel ; Kelm, Malte ; Kevil, Christopher G. ; Kim-Shapiro, Daniel B. ; Kozlov, Andrey V. ; Lancaster, Jack R. ; Lefer, David J. ; McColl, Kenneth ; McCurry, Kenneth ; Patel, Rakesh P. ; Petersson, Joel ; Rassaf, Tienush ; Reutov, Valentin P. ; Richter-Addo, George B. ; Schechter, Alan ; Shiva, Sruti ; Tsuchiya, Koichiro ; Van Faassen, Ernst E. ; Webb, Andrew J. ; Zuckerbraun, Brian S. ; Zweier, Jay L. ; Weitzberg, Eddie. / Nitrate and nitrite in biology, nutrition and therapeutics. In: Nature Chemical Biology. 2009 ; Vol. 5, No. 12. pp. 865-869.
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