Nimodipine, a voltage-sensitive calcium channel antagonist, fails to ameliorate light-induced retinal degeneration in rat.

J. P. Li, D. P. Edward, T. T. Lam, M. O. Tso

Research output: Contribution to journalArticle

Abstract

A recent study demonstrated the amelioration of light-induced photoreceptor degeneration by flunarizine and suggested that the protective effect achieved by the drug may be due to the inhibition of inositol 1,4,5-trisphosphate-induced calcium release from intracellular stores or the inhibition of calcium entry through putative voltage-sensitive calcium channels. In the current study, we investigated the effect of nimodipine, a specific voltage-sensitive calcium channel blocker, in light-induced retinal degeneration to further define the factors involved in the retinal degenerative process. Morphological, morphometric, and biochemical results demonstrated that nimodipine was ineffective in ameliorating light-induced retinal degeneration, and implied that calcium entry through voltage-sensitive channels is unlikely to be involved in this disease process, and inositol 1,4,5-trisphosphate-induced calcium release from intracellular stores may play a dominant role in light-induced photoreceptor cell damage.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalResearch communications in chemical pathology and pharmacology
Volume72
Issue number3
StatePublished - Jun 1991

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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