NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report

Howard M. Shulman; Diana M. Cardona; Joel K. Greenson; Sangeeta Hingorani; Thomas Horn; Elisabeth Huber; Andreas Kreft; Thomas Longerich; Thomas Morton; David Myerson; Victor G. Prieto; Avi Rosenberg; Nathaniel Treister; Kay Washington; Mirjana Ziemer; Steven Z. Pavletic; Stephanie J. Lee; Mary E.D. Flowers; Kirk R. Schultz; Madan Jagasia; Paul J. Martin; Georgia B. Vogelsang; David E. Kleiner

doi:10.1016/j.bbmt.2014.12.031

NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report

Howard M. Shulman, Diana M. Cardona, Joel K. Greenson, Sangeeta Hingorani, Thomas Horn, Elisabeth Huber, Andreas Kreft, Thomas Longerich, Thomas Morton, David Myerson, Victor G. Prieto, Avi Rosenberg, Nathaniel Treister, Kay Washington, Mirjana Ziemer, Steven Z. Pavletic, Stephanie J. Lee, Mary E.D. Flowers, Kirk R. Schultz, Madan JagasiaPaul J. Martin, Georgia B. Vogelsang, David E. Kleiner

School of Medicine

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

The 2005 National Institute of Health (NIH) Consensus Conference outlined histopathological diagnostic criteria for the major organ systems affected by both acute and chronic graft-versus-host disease (GVHD). The 2014 Consensus Conference led to this updated document with new information from histopathological studies of GVHD in the gut, liver, skin, and oral mucosa and an expanded discussion of GVHD in the lungs and kidneys. The recommendations for final histological diagnostic categories have been simplified from 4 categories to 3: no GVHD, possible GVHD, and likely GVHD, based on better reproducibility achieved by combining the previous categories of "consistent with GVHD" and "definite GVHD" into the single category of "likely GVHD." Issues remain in the histopathological characterization of GVHD, particularly with respect to the threshold of histological changes required for diagnostic certainty. Guidance is provided for the incorporation of biopsy information into prospective clinical studies of GVHD, particularly with respect to biomarker validation.

Original language	English (US)
Pages (from-to)	589-603
Number of pages	15
Journal	Biology of Blood and Marrow Transplantation
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.bbmt.2014.12.031
State	Published - Apr 1 2015

Keywords

Allogeneic hematopoietic cell transplantation
Chronic graft-versus-host disease
Consensus
Diagnosis
Histology
Pathology

ASJC Scopus subject areas

Hematology
Transplantation

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10.1016/j.bbmt.2014.12.031

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Shulman, H. M., Cardona, D. M., Greenson, J. K., Hingorani, S., Horn, T., Huber, E., Kreft, A., Longerich, T., Morton, T., Myerson, D., Prieto, V. G., Rosenberg, A., Treister, N., Washington, K., Ziemer, M., Pavletic, S. Z., Lee, S. J., Flowers, M. E. D., Schultz, K. R., ... Kleiner, D. E. (2015). NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report. Biology of Blood and Marrow Transplantation, 21(4), 589-603. https://doi.org/10.1016/j.bbmt.2014.12.031

NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report. / Shulman, Howard M.; Cardona, Diana M.; Greenson, Joel K. et al.
In: Biology of Blood and Marrow Transplantation, Vol. 21, No. 4, 01.04.2015, p. 589-603.

Research output: Contribution to journal › Article › peer-review

Shulman, HM, Cardona, DM, Greenson, JK, Hingorani, S, Horn, T, Huber, E, Kreft, A, Longerich, T, Morton, T, Myerson, D, Prieto, VG, Rosenberg, A, Treister, N, Washington, K, Ziemer, M, Pavletic, SZ, Lee, SJ, Flowers, MED, Schultz, KR, Jagasia, M, Martin, PJ, Vogelsang, GB & Kleiner, DE 2015, 'NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report', Biology of Blood and Marrow Transplantation, vol. 21, no. 4, pp. 589-603. https://doi.org/10.1016/j.bbmt.2014.12.031

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abstract = "The 2005 National Institute of Health (NIH) Consensus Conference outlined histopathological diagnostic criteria for the major organ systems affected by both acute and chronic graft-versus-host disease (GVHD). The 2014 Consensus Conference led to this updated document with new information from histopathological studies of GVHD in the gut, liver, skin, and oral mucosa and an expanded discussion of GVHD in the lungs and kidneys. The recommendations for final histological diagnostic categories have been simplified from 4 categories to 3: no GVHD, possible GVHD, and likely GVHD, based on better reproducibility achieved by combining the previous categories of {"}consistent with GVHD{"} and {"}definite GVHD{"} into the single category of {"}likely GVHD.{"} Issues remain in the histopathological characterization of GVHD, particularly with respect to the threshold of histological changes required for diagnostic certainty. Guidance is provided for the incorporation of biopsy information into prospective clinical studies of GVHD, particularly with respect to biomarker validation.",

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AU - Lee, Stephanie J.

AU - Flowers, Mary E.D.

AU - Schultz, Kirk R.

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AU - Martin, Paul J.

AU - Vogelsang, Georgia B.

AU - Kleiner, David E.

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NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report

Abstract

Keywords

ASJC Scopus subject areas

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