NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report

Howard M. Shulman, Diana M. Cardona, Joel K. Greenson, Sangeeta Hingorani, Thomas Horn, Elisabeth Huber, Andreas Kreft, Thomas Longerich, Thomas Morton, David Myerson, Victor G. Prieto, Avi Rosenberg, Nathaniel Treister, Kay Washington, Mirjana Ziemer, Steven Z. Pavletic, Stephanie J. Lee, Mary E.D. Flowers, Kirk R. Schultz, Madan JagasiaPaul J. Martin, Georgia B. Vogelsang, David E. Kleiner

Research output: Contribution to journalArticle

Abstract

The 2005 National Institute of Health (NIH) Consensus Conference outlined histopathological diagnostic criteria for the major organ systems affected by both acute and chronic graft-versus-host disease (GVHD). The 2014 Consensus Conference led to this updated document with new information from histopathological studies of GVHD in the gut, liver, skin, and oral mucosa and an expanded discussion of GVHD in the lungs and kidneys. The recommendations for final histological diagnostic categories have been simplified from 4 categories to 3: no GVHD, possible GVHD, and likely GVHD, based on better reproducibility achieved by combining the previous categories of "consistent with GVHD" and "definite GVHD" into the single category of "likely GVHD." Issues remain in the histopathological characterization of GVHD, particularly with respect to the threshold of histological changes required for diagnostic certainty. Guidance is provided for the incorporation of biopsy information into prospective clinical studies of GVHD, particularly with respect to biomarker validation.

Original languageEnglish (US)
Pages (from-to)589-603
Number of pages15
JournalBiology of Blood and Marrow Transplantation
Volume21
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Allogeneic hematopoietic cell transplantation
  • Chronic graft-versus-host disease
  • Consensus
  • Diagnosis
  • Histology
  • Pathology

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report'. Together they form a unique fingerprint.

  • Cite this

    Shulman, H. M., Cardona, D. M., Greenson, J. K., Hingorani, S., Horn, T., Huber, E., Kreft, A., Longerich, T., Morton, T., Myerson, D., Prieto, V. G., Rosenberg, A., Treister, N., Washington, K., Ziemer, M., Pavletic, S. Z., Lee, S. J., Flowers, M. E. D., Schultz, K. R., ... Kleiner, D. E. (2015). NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report. Biology of Blood and Marrow Transplantation, 21(4), 589-603. https://doi.org/10.1016/j.bbmt.2014.12.031