Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding

Ian Creese; Solomon H. Snyder

doi:10.1016/0014-2999(79)90184-5

Nigrostriatal lesions enhance striatal ³H-apomorphine and ³H-spiroperidol binding

Ian Creese, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

204 Scopus citations

Abstract

3ollowing unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both ³H-apomorphine and ³H-spiroperidol in the striatum is increased. In rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels.

Original language	English (US)
Pages (from-to)	277-281
Number of pages	5
Journal	European Journal of Pharmacology
Volume	56
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(79)90184-5
State	Published - Jun 15 1979

Keywords

Dopamine receptor
H-Apomorphine binding
H-Spiroperidol binding
Supeesensitivity

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(79)90184-5

Cite this

@article{716ae4145e9e4c6aa222efa80e74922d,

title = "Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding",

abstract = "3ollowing unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both 3H-apomorphine and 3H-spiroperidol in the striatum is increased. In rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels.",

keywords = "Dopamine receptor, H-Apomorphine binding, H-Spiroperidol binding, Supeesensitivity",

author = "Ian Creese and Snyder, {Solomon H.}",

note = "Funding Information: Supported by USPHS grant MH-18501,t he ScottishR ite Foundationth, eM cKnightF oundation andt heJ ohnA. HartfordF oundationIn,c .",

year = "1979",

month = jun,

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doi = "10.1016/0014-2999(79)90184-5",

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journal = "European Journal of Pharmacology",

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T1 - Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding

AU - Creese, Ian

AU - Snyder, Solomon H.

N1 - Funding Information: Supported by USPHS grant MH-18501,t he ScottishR ite Foundationth, eM cKnightF oundation andt heJ ohnA. HartfordF oundationIn,c .

PY - 1979/6/15

Y1 - 1979/6/15

N2 - 3ollowing unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both 3H-apomorphine and 3H-spiroperidol in the striatum is increased. In rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels.

AB - 3ollowing unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both 3H-apomorphine and 3H-spiroperidol in the striatum is increased. In rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels.

KW - Dopamine receptor

KW - H-Apomorphine binding

KW - H-Spiroperidol binding

KW - Supeesensitivity

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