TY - JOUR
T1 - NightBlindness during pregnancy in Nepal
T2 - Links to nutrition and health
AU - Christian, P.
AU - West, K. P.
AU - Khatry, Subarna
AU - Pradhan, L. E.
AU - Leclerq, S.
AU - Stoltzfijs, R. J.
AU - Katz, J.
AU - Hartley, M. E.
AU - Shrestha, S. R.
PY - 1996
Y1 - 1996
N2 - Night blindness (XN) occurs in an estimated 10-20% of pregnant women in rural Nepal. Risk factors for XN during pregnancy were assessed using a matched case-control design in the south eastern plains of Nepal. Cases were XN pregnant women identified through a surveillance system and verified by an interview. Randomly selected non-XN controls were matched for months of gestation. Cases and controls (N=90 pairs) were interviewed and examined at home soon after being identified. Controls were more likely (95% CI>1) to have consumed milk (Odds Ratio=2.4), whey (OR=1.2), mangoes (OR=7), and dark green leaves (OR=2.4) in the previous week. Serum retinol of cases was 10 ng/dl lower than the controls (p< 0001), and was associated with intakes of vitamin A foods. Weight, mid arm circumference and Hb levels of cases were also significantly lower in cases. XN women were more likely to report a poor appetite (OR=3.0), nausea(OR=3.5), diarrhea (OR=3.0), painful urination (OR=2.2), and lower abdominal pain (OR- 2.0). XN during pregnancy appears to be related to vitamin A deficiency, anemia and increased risk of morbidity thus posing a significant risk to women's reproductive health and nutrition. Funded by USAID Office of Health & Nutrition, Washington DC.
AB - Night blindness (XN) occurs in an estimated 10-20% of pregnant women in rural Nepal. Risk factors for XN during pregnancy were assessed using a matched case-control design in the south eastern plains of Nepal. Cases were XN pregnant women identified through a surveillance system and verified by an interview. Randomly selected non-XN controls were matched for months of gestation. Cases and controls (N=90 pairs) were interviewed and examined at home soon after being identified. Controls were more likely (95% CI>1) to have consumed milk (Odds Ratio=2.4), whey (OR=1.2), mangoes (OR=7), and dark green leaves (OR=2.4) in the previous week. Serum retinol of cases was 10 ng/dl lower than the controls (p< 0001), and was associated with intakes of vitamin A foods. Weight, mid arm circumference and Hb levels of cases were also significantly lower in cases. XN women were more likely to report a poor appetite (OR=3.0), nausea(OR=3.5), diarrhea (OR=3.0), painful urination (OR=2.2), and lower abdominal pain (OR- 2.0). XN during pregnancy appears to be related to vitamin A deficiency, anemia and increased risk of morbidity thus posing a significant risk to women's reproductive health and nutrition. Funded by USAID Office of Health & Nutrition, Washington DC.
UR - http://www.scopus.com/inward/record.url?scp=26544466802&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26544466802&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:26544466802
SN - 0892-6638
VL - 10
SP - A246
JO - FASEB Journal
JF - FASEB Journal
IS - 3
ER -