Nicotinic receptor dependent regulation of cough and other airway defensive reflexes

Mayuko Tao, Qi Liu, Yasunari Miyazaki, Brendan J Canning

Research output: Contribution to journalReview article

Abstract

Nicotinic receptor activation in the airways evokes airway defensive reflexes including cough. These reflexes are the direct result of bronchopulmonary afferent nerve activation, which may occur directly, through activation of nicotinic receptors expressed on the terminals of airway sensory nerves, or indirectly, secondary to the end organ effects associated with autonomic nerve stimulation. The irritating effects of nicotine delivered topically to the airways are counterbalanced by an inhibitory effect of nicotinic receptor activation in the central nervous system. We present evidence that these nicotinic receptors are components of essential transducing and encoding mechanisms regulating airway defense.

Original languageEnglish (US)
Article number101810
JournalPulmonary Pharmacology and Therapeutics
Volume58
DOIs
StatePublished - Oct 1 2019

Fingerprint

Nicotinic Receptors
Cough
Reflex
Chemical activation
Autonomic Pathways
Nicotine
Neurology
Central Nervous System

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Nicotinic receptor dependent regulation of cough and other airway defensive reflexes. / Tao, Mayuko; Liu, Qi; Miyazaki, Yasunari; Canning, Brendan J.

In: Pulmonary Pharmacology and Therapeutics, Vol. 58, 101810, 01.10.2019.

Research output: Contribution to journalReview article

@article{775447dcf59a4faab85704a30f0fe0bd,
title = "Nicotinic receptor dependent regulation of cough and other airway defensive reflexes",
abstract = "Nicotinic receptor activation in the airways evokes airway defensive reflexes including cough. These reflexes are the direct result of bronchopulmonary afferent nerve activation, which may occur directly, through activation of nicotinic receptors expressed on the terminals of airway sensory nerves, or indirectly, secondary to the end organ effects associated with autonomic nerve stimulation. The irritating effects of nicotine delivered topically to the airways are counterbalanced by an inhibitory effect of nicotinic receptor activation in the central nervous system. We present evidence that these nicotinic receptors are components of essential transducing and encoding mechanisms regulating airway defense.",
author = "Mayuko Tao and Qi Liu and Yasunari Miyazaki and Canning, {Brendan J}",
year = "2019",
month = "10",
day = "1",
doi = "10.1016/j.pupt.2019.101810",
language = "English (US)",
volume = "58",
journal = "Pulmonary Pharmacology and Therapeutics",
issn = "1094-5539",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Nicotinic receptor dependent regulation of cough and other airway defensive reflexes

AU - Tao, Mayuko

AU - Liu, Qi

AU - Miyazaki, Yasunari

AU - Canning, Brendan J

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Nicotinic receptor activation in the airways evokes airway defensive reflexes including cough. These reflexes are the direct result of bronchopulmonary afferent nerve activation, which may occur directly, through activation of nicotinic receptors expressed on the terminals of airway sensory nerves, or indirectly, secondary to the end organ effects associated with autonomic nerve stimulation. The irritating effects of nicotine delivered topically to the airways are counterbalanced by an inhibitory effect of nicotinic receptor activation in the central nervous system. We present evidence that these nicotinic receptors are components of essential transducing and encoding mechanisms regulating airway defense.

AB - Nicotinic receptor activation in the airways evokes airway defensive reflexes including cough. These reflexes are the direct result of bronchopulmonary afferent nerve activation, which may occur directly, through activation of nicotinic receptors expressed on the terminals of airway sensory nerves, or indirectly, secondary to the end organ effects associated with autonomic nerve stimulation. The irritating effects of nicotine delivered topically to the airways are counterbalanced by an inhibitory effect of nicotinic receptor activation in the central nervous system. We present evidence that these nicotinic receptors are components of essential transducing and encoding mechanisms regulating airway defense.

UR - http://www.scopus.com/inward/record.url?scp=85069852050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069852050&partnerID=8YFLogxK

U2 - 10.1016/j.pupt.2019.101810

DO - 10.1016/j.pupt.2019.101810

M3 - Review article

C2 - 31181318

AN - SCOPUS:85069852050

VL - 58

JO - Pulmonary Pharmacology and Therapeutics

JF - Pulmonary Pharmacology and Therapeutics

SN - 1094-5539

M1 - 101810

ER -