Abstract
Nicotinic receptor activation in the airways evokes airway defensive reflexes including cough. These reflexes are the direct result of bronchopulmonary afferent nerve activation, which may occur directly, through activation of nicotinic receptors expressed on the terminals of airway sensory nerves, or indirectly, secondary to the end organ effects associated with autonomic nerve stimulation. The irritating effects of nicotine delivered topically to the airways are counterbalanced by an inhibitory effect of nicotinic receptor activation in the central nervous system. We present evidence that these nicotinic receptors are components of essential transducing and encoding mechanisms regulating airway defense.
| Original language | English (US) |
|---|---|
| Article number | 101810 |
| Journal | Pulmonary Pharmacology and Therapeutics |
| Volume | 58 |
| DOIs | |
| State | Published - Oct 1 2019 |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Biochemistry, medical
- Pharmacology (medical)
Cite this
Nicotinic receptor dependent regulation of cough and other airway defensive reflexes. / Tao, Mayuko; Liu, Qi; Miyazaki, Yasunari; Canning, Brendan J.
In: Pulmonary Pharmacology and Therapeutics, Vol. 58, 101810, 01.10.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Nicotinic receptor dependent regulation of cough and other airway defensive reflexes
AU - Tao, Mayuko
AU - Liu, Qi
AU - Miyazaki, Yasunari
AU - Canning, Brendan J
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Nicotinic receptor activation in the airways evokes airway defensive reflexes including cough. These reflexes are the direct result of bronchopulmonary afferent nerve activation, which may occur directly, through activation of nicotinic receptors expressed on the terminals of airway sensory nerves, or indirectly, secondary to the end organ effects associated with autonomic nerve stimulation. The irritating effects of nicotine delivered topically to the airways are counterbalanced by an inhibitory effect of nicotinic receptor activation in the central nervous system. We present evidence that these nicotinic receptors are components of essential transducing and encoding mechanisms regulating airway defense.
AB - Nicotinic receptor activation in the airways evokes airway defensive reflexes including cough. These reflexes are the direct result of bronchopulmonary afferent nerve activation, which may occur directly, through activation of nicotinic receptors expressed on the terminals of airway sensory nerves, or indirectly, secondary to the end organ effects associated with autonomic nerve stimulation. The irritating effects of nicotine delivered topically to the airways are counterbalanced by an inhibitory effect of nicotinic receptor activation in the central nervous system. We present evidence that these nicotinic receptors are components of essential transducing and encoding mechanisms regulating airway defense.
UR - http://www.scopus.com/inward/record.url?scp=85069852050&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069852050&partnerID=8YFLogxK
U2 - 10.1016/j.pupt.2019.101810
DO - 10.1016/j.pupt.2019.101810
M3 - Review article
C2 - 31181318
AN - SCOPUS:85069852050
VL - 58
JO - Pulmonary Pharmacology and Therapeutics
JF - Pulmonary Pharmacology and Therapeutics
SN - 1094-5539
M1 - 101810
ER -