Nicotinic acetylcholine binding sites in Alzheimer's disease

Peter J. Whitehouse, Andrea M. Martino, Piero G. Antuono, Pedro R. Lowenstein, Joseph T. Coyle, Donald L. Price, Kenneth J. Kellar

Research output: Contribution to journalArticle

Abstract

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.

Original languageEnglish (US)
Pages (from-to)146-151
Number of pages6
JournalBrain Research
Volume371
Issue number1
DOIs
StatePublished - Apr 16 1986

Fingerprint

Acetylcholine
Alzheimer Disease
Binding Sites
Cholinergic Agents
Nicotinic Receptors
Cholinergic Receptors
Nicotine
Cerebral Cortex
Autopsy

Keywords

  • acetylcholine
  • Alzheimer's disease
  • choline acetyltransferase
  • nicotinic cholinergic receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Whitehouse, P. J., Martino, A. M., Antuono, P. G., Lowenstein, P. R., Coyle, J. T., Price, D. L., & Kellar, K. J. (1986). Nicotinic acetylcholine binding sites in Alzheimer's disease. Brain Research, 371(1), 146-151. https://doi.org/10.1016/0006-8993(86)90819-X

Nicotinic acetylcholine binding sites in Alzheimer's disease. / Whitehouse, Peter J.; Martino, Andrea M.; Antuono, Piero G.; Lowenstein, Pedro R.; Coyle, Joseph T.; Price, Donald L.; Kellar, Kenneth J.

In: Brain Research, Vol. 371, No. 1, 16.04.1986, p. 146-151.

Research output: Contribution to journalArticle

Whitehouse, PJ, Martino, AM, Antuono, PG, Lowenstein, PR, Coyle, JT, Price, DL & Kellar, KJ 1986, 'Nicotinic acetylcholine binding sites in Alzheimer's disease', Brain Research, vol. 371, no. 1, pp. 146-151. https://doi.org/10.1016/0006-8993(86)90819-X
Whitehouse PJ, Martino AM, Antuono PG, Lowenstein PR, Coyle JT, Price DL et al. Nicotinic acetylcholine binding sites in Alzheimer's disease. Brain Research. 1986 Apr 16;371(1):146-151. https://doi.org/10.1016/0006-8993(86)90819-X
Whitehouse, Peter J. ; Martino, Andrea M. ; Antuono, Piero G. ; Lowenstein, Pedro R. ; Coyle, Joseph T. ; Price, Donald L. ; Kellar, Kenneth J. / Nicotinic acetylcholine binding sites in Alzheimer's disease. In: Brain Research. 1986 ; Vol. 371, No. 1. pp. 146-151.
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