@article{e69db1c28595446b9f806301cb05ebe0,
title = "Nicotinic acetylcholine binding sites in Alzheimer's disease",
abstract = "In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.",
keywords = "Alzheimer's disease, acetylcholine, choline acetyltransferase, nicotinic cholinergic receptor",
author = "Whitehouse, {Peter J.} and Martino, {Andrea M.} and Antuono, {Piero G.} and Lowenstein, {Pedro R.} and Coyle, {Joseph T.} and Price, {Donald L.} and Kellar, {Kenneth J.}",
note = "Funding Information: The authors acknowledge the advice of Dr. Gary Chase concerning statistical analysis as well as the technical assistance of Bruce Jones and Kendall Marcus. Ms. Carla Jordon provided assistance preparing the manuscript. This work was supported by grants from the U.S. Public Health Service (NIH NS 10580, AG 03359, AG 05146, and NS 20471) and from the US Army (USAMRDCDAMD 17-83-C-3113) as well as funds from The McKnight Foundation, The Commonwealth Fund, the Alfred P. Sloan Foundation, and the Scottish Rite Schizophrenia Research Program (NMJ USA).",
year = "1986",
month = apr,
day = "16",
doi = "10.1016/0006-8993(86)90819-X",
language = "English (US)",
volume = "371",
pages = "146--151",
journal = "Brain research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",
}