Nicotinic acetylcholine binding sites in Alzheimer's disease

Peter J. Whitehouse, Andrea M. Martino, Piero G. Antuono, Pedro R. Lowenstein, Joseph T. Coyle, Donald L. Price, Kenneth J. Kellar

Research output: Contribution to journalArticle

Abstract

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.

Original languageEnglish (US)
Pages (from-to)146-151
Number of pages6
JournalBrain research
Volume371
Issue number1
DOIs
StatePublished - Apr 16 1986

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Keywords

  • Alzheimer's disease
  • acetylcholine
  • choline acetyltransferase
  • nicotinic cholinergic receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Whitehouse, P. J., Martino, A. M., Antuono, P. G., Lowenstein, P. R., Coyle, J. T., Price, D. L., & Kellar, K. J. (1986). Nicotinic acetylcholine binding sites in Alzheimer's disease. Brain research, 371(1), 146-151. https://doi.org/10.1016/0006-8993(86)90819-X