Nicotine reinforcement in never-smokers

Angela N. Duke, Matthew W Johnson, Chad J. Reissig, Roland R Griffiths

Research output: Contribution to journalArticle

Abstract

Rationale: Global tobacco-related mortality dwarfs that of all other drugs. Nicotine is believed to be the primary agent responsible for tobacco use and addiction. However, nicotine is a relatively weak and inconsistent reinforcer in nonhumans and nicotine reinforcement has not been demonstrated in never-smokers. Objectives: This study investigated the discriminative, subjective, and reinforcing effects of nicotine in never-smokers. Methods: Eighteen never-smokers (

Original languageEnglish (US)
Pages (from-to)4243-4252
Number of pages10
JournalPsychopharmacology
Volume232
Issue number23
DOIs
StatePublished - Sep 8 2015

Fingerprint

Nicotine
Tobacco Use
Tobacco
Mortality
Reinforcement (Psychology)
Pharmaceutical Preparations

Keywords

  • Drug discrimination
  • Never-smoker
  • Nicotine
  • Oral
  • Reinforcement
  • Self-administration
  • Subjective effects

ASJC Scopus subject areas

  • Pharmacology

Cite this

Nicotine reinforcement in never-smokers. / Duke, Angela N.; Johnson, Matthew W; Reissig, Chad J.; Griffiths, Roland R.

In: Psychopharmacology, Vol. 232, No. 23, 08.09.2015, p. 4243-4252.

Research output: Contribution to journalArticle

Duke, Angela N. ; Johnson, Matthew W ; Reissig, Chad J. ; Griffiths, Roland R. / Nicotine reinforcement in never-smokers. In: Psychopharmacology. 2015 ; Vol. 232, No. 23. pp. 4243-4252.
@article{4a47ac128b9d47eb979b81be8fb17fff,
title = "Nicotine reinforcement in never-smokers",
abstract = "Rationale: Global tobacco-related mortality dwarfs that of all other drugs. Nicotine is believed to be the primary agent responsible for tobacco use and addiction. However, nicotine is a relatively weak and inconsistent reinforcer in nonhumans and nicotine reinforcement has not been demonstrated in never-smokers. Objectives: This study investigated the discriminative, subjective, and reinforcing effects of nicotine in never-smokers. Methods: Eighteen never-smokers (",
keywords = "Drug discrimination, Never-smoker, Nicotine, Oral, Reinforcement, Self-administration, Subjective effects",
author = "Duke, {Angela N.} and Johnson, {Matthew W} and Reissig, {Chad J.} and Griffiths, {Roland R}",
year = "2015",
month = "9",
day = "8",
doi = "10.1007/s00213-015-4053-4",
language = "English (US)",
volume = "232",
pages = "4243--4252",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "23",

}

TY - JOUR

T1 - Nicotine reinforcement in never-smokers

AU - Duke, Angela N.

AU - Johnson, Matthew W

AU - Reissig, Chad J.

AU - Griffiths, Roland R

PY - 2015/9/8

Y1 - 2015/9/8

N2 - Rationale: Global tobacco-related mortality dwarfs that of all other drugs. Nicotine is believed to be the primary agent responsible for tobacco use and addiction. However, nicotine is a relatively weak and inconsistent reinforcer in nonhumans and nicotine reinforcement has not been demonstrated in never-smokers. Objectives: This study investigated the discriminative, subjective, and reinforcing effects of nicotine in never-smokers. Methods: Eighteen never-smokers (

AB - Rationale: Global tobacco-related mortality dwarfs that of all other drugs. Nicotine is believed to be the primary agent responsible for tobacco use and addiction. However, nicotine is a relatively weak and inconsistent reinforcer in nonhumans and nicotine reinforcement has not been demonstrated in never-smokers. Objectives: This study investigated the discriminative, subjective, and reinforcing effects of nicotine in never-smokers. Methods: Eighteen never-smokers (

KW - Drug discrimination

KW - Never-smoker

KW - Nicotine

KW - Oral

KW - Reinforcement

KW - Self-administration

KW - Subjective effects

UR - http://www.scopus.com/inward/record.url?scp=84945452644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945452644&partnerID=8YFLogxK

U2 - 10.1007/s00213-015-4053-4

DO - 10.1007/s00213-015-4053-4

M3 - Article

VL - 232

SP - 4243

EP - 4252

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 23

ER -