Abstract
Rationale: Global tobacco-related mortality dwarfs that of all other drugs. Nicotine is believed to be the primary agent responsible for tobacco use and addiction. However, nicotine is a relatively weak and inconsistent reinforcer in nonhumans and nicotine reinforcement has not been demonstrated in never-smokers. Objectives: This study investigated the discriminative, subjective, and reinforcing effects of nicotine in never-smokers. Methods: Eighteen never-smokers (
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4243-4252 |
| Number of pages | 10 |
| Journal | Psychopharmacology |
| Volume | 232 |
| Issue number | 23 |
| DOIs | |
| State | Published - Sep 8 2015 |
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Keywords
- Drug discrimination
- Never-smoker
- Nicotine
- Oral
- Reinforcement
- Self-administration
- Subjective effects
ASJC Scopus subject areas
- Pharmacology
Cite this
Nicotine reinforcement in never-smokers. / Duke, Angela N.; Johnson, Matthew W; Reissig, Chad J.; Griffiths, Roland R.
In: Psychopharmacology, Vol. 232, No. 23, 08.09.2015, p. 4243-4252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nicotine reinforcement in never-smokers
AU - Duke, Angela N.
AU - Johnson, Matthew W
AU - Reissig, Chad J.
AU - Griffiths, Roland R
PY - 2015/9/8
Y1 - 2015/9/8
N2 - Rationale: Global tobacco-related mortality dwarfs that of all other drugs. Nicotine is believed to be the primary agent responsible for tobacco use and addiction. However, nicotine is a relatively weak and inconsistent reinforcer in nonhumans and nicotine reinforcement has not been demonstrated in never-smokers. Objectives: This study investigated the discriminative, subjective, and reinforcing effects of nicotine in never-smokers. Methods: Eighteen never-smokers (
AB - Rationale: Global tobacco-related mortality dwarfs that of all other drugs. Nicotine is believed to be the primary agent responsible for tobacco use and addiction. However, nicotine is a relatively weak and inconsistent reinforcer in nonhumans and nicotine reinforcement has not been demonstrated in never-smokers. Objectives: This study investigated the discriminative, subjective, and reinforcing effects of nicotine in never-smokers. Methods: Eighteen never-smokers (
KW - Drug discrimination
KW - Never-smoker
KW - Nicotine
KW - Oral
KW - Reinforcement
KW - Self-administration
KW - Subjective effects
UR - http://www.scopus.com/inward/record.url?scp=84945452644&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945452644&partnerID=8YFLogxK
U2 - 10.1007/s00213-015-4053-4
DO - 10.1007/s00213-015-4053-4
M3 - Article
VL - 232
SP - 4243
EP - 4252
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 23
ER -