Nicotine induced up-regulation of nicotinic receptors in CD-1 mice demonstrated with an in vivo radiotracer: Gender differences

Takao Mochizuki, Victor L. Villemagne, Ursula Scheffel, Robert F. Dannals, Paige Finley, Yougen Zhan, Henry N. Wagner, John L. Musachio

Research output: Contribution to journalArticlepeer-review

Abstract

Up-regulation of brain nicotinic receptors (nAChRs) by chronic nicotine treatment has chiefly been demonstrated by in vitro binding assays. Here, we report that up-regulation of nAChRs in CD-1 mice can be detected using a specific in vivo radioligand for nAChRs, [125I]IPH. After 10 days of (-)- nicotine administration, male and female mice demonstrated a significant elevation of [125I]IPH binding in all brain regions studied. [125I]IPH uptake also displayed significant gender differences with male animals showing a more pronounced increase in [125I]IPH accumulation.

Original languageEnglish (US)
Pages (from-to)116-118
Number of pages3
JournalSynapse
Volume30
Issue number1
DOIs
StatePublished - Sep 1 1998

Keywords

  • Brain
  • Gender
  • Mice
  • Nicotine
  • Radiotracer

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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