Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model

Nima Tirgan, Gabriela A. Kulp, Praveena Gupta, Adam Boretsky, Tomasz A. Wiraszka, Bernard Godley, Ronald G. Tilton, Massoud Motamedi

Research output: Contribution to journalArticle

Abstract

Diabetes and smoking are known risk factors for cataract development. In this study, we evaluated the effect of nicotine on the progression of cataracts in a type 1 diabetic rat model. Diabetes was induced in Sprague-Dawley rats by a single injection of 65 mg/kg streptozotocin. Daily nicotine injections were administered subcutaneously. Forty-five rats were divided into groups of diabetics with and without nicotine treatment and controls with and without nicotine treatment. Progression of lens opacity was monitored using a slit lamp biomicroscope and scores were assigned. To assess whether systemic inflammation played a role in mediating cataractogenesis, we studied serum levels of eotaxin, IL-6, and IL-4. The levels of the measured cytokines increased significantly in nicotine-treated and untreated diabetic animals versus controls and demonstrated a positive trend in the nicotine-treated diabetic rats. Our data suggest the presence of a synergistic relationship between nicotine and diabetes that accelerated cataract formation via inflammatory mediators.

Original languageEnglish (US)
Article number349320
JournalExperimental Diabetes Research
Volume2012
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Nicotine
Cataract
Injections
Streptozocin
Rat
Interleukin-4
Sprague Dawley Rats
Interleukin-6
Diabetes
Smoking
Cytokines
Inflammation
Therapeutics
Progression
Serum

ASJC Scopus subject areas

  • Medicine(all)
  • Endocrinology, Diabetes and Metabolism
  • Music

Cite this

Tirgan, N., Kulp, G. A., Gupta, P., Boretsky, A., Wiraszka, T. A., Godley, B., ... Motamedi, M. (2012). Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model. Experimental Diabetes Research, 2012, [349320]. https://doi.org/10.1155/2012/349320

Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model. / Tirgan, Nima; Kulp, Gabriela A.; Gupta, Praveena; Boretsky, Adam; Wiraszka, Tomasz A.; Godley, Bernard; Tilton, Ronald G.; Motamedi, Massoud.

In: Experimental Diabetes Research, Vol. 2012, 349320, 2012.

Research output: Contribution to journalArticle

Tirgan, N, Kulp, GA, Gupta, P, Boretsky, A, Wiraszka, TA, Godley, B, Tilton, RG & Motamedi, M 2012, 'Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model', Experimental Diabetes Research, vol. 2012, 349320. https://doi.org/10.1155/2012/349320
Tirgan, Nima ; Kulp, Gabriela A. ; Gupta, Praveena ; Boretsky, Adam ; Wiraszka, Tomasz A. ; Godley, Bernard ; Tilton, Ronald G. ; Motamedi, Massoud. / Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model. In: Experimental Diabetes Research. 2012 ; Vol. 2012.
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