Nicotine delivery systems

Saul Shiffman, Reginald V. Fant, August R. Buchhalter, Joseph G. Gitchell, Jack E. Henningfield

Research output: Contribution to journalArticlepeer-review

Abstract

Over the past 20 years, medicinal nicotine has been used to aid smoking cessation, and has led to a significant increase in the number of smokers who successfully quit. This review describes currently available medicinal nicotine products, which include nicotine patch, gum, lozenge, nasal spray, inhaler and sublingual tablet, including their pharmacokinetics and recommended dosing. New developments in nicotine delivery that could further increase cessation rates include high-dose patches, rapid release gum, combined patch and acute forms, and several novel channels for nicotine delivery, such as nicotine drink, straw, lollipop and a pulmonary inhaler. New applications of existing and novel medicinal nicotine products may include relapse prevention, nicotine maintenance, temporary withdrawal management, reduced smoking and gradual quitting.

Original languageEnglish (US)
Pages (from-to)563-577
Number of pages15
JournalExpert Opinion on Drug Delivery
Volume2
Issue number3
DOIs
StatePublished - May 2005

Keywords

  • Gum
  • Inhaler
  • Lozenge
  • Nasal spray
  • Nicotine
  • Patch
  • Tablet
  • Tobacco

ASJC Scopus subject areas

  • Pharmaceutical Science

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