Nicotine decreases the cytotoxicity of doxorubicin towards MCF-7 and KB-3.1 human cancer cells in culture

Yanfei Zhou, Xinbin Gu, Ebrahim Ashayeri, Renshu Zhang, Rajagopalan Sridhar

Research output: Contribution to journalArticlepeer-review

Abstract

The harmful effects of tobacco use and nicotine are well known. There is strong epidemiological evidence for smoking as a risk factor for cancer of the lung and oral cavity. The evidence for second-hand smoke as a risk factor for breast cancer is rapidly accumulating. The anthracycline doxorubicin is used in the treatment of many types of malignancies, including breast cancer. The effect of nicotine on doxorubicin toxicity was evaluated in MCF-7 and KB-3.1 cancer cell cultures. Nicotine partially inhibited doxorubicin toxicity towards MCF-7 and KB-3.1 cells, as judged by clonogenicity and flow cytometry assays. Flow cytometric analysis showed that

Original languageEnglish (US)
Pages (from-to)319-327
Number of pages9
JournalJournal of the National Medical Association
Volume99
Issue number4
StatePublished - Apr 2007
Externally publishedYes

Keywords

  • Cancer
  • Chemotherapy
  • Doxorubicin
  • Nicotine

ASJC Scopus subject areas

  • Medicine(all)

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