NIAID Workshop, Memphis, Tennessee, 25-26 March 1997: Statistical issues for HIV surrogate endpoints: Point/counterpoint

Jeffrey M. Albert, John P.A. Ioannidis, Patricia Reichelderfer, Brian Conway, Robert W. Coombs, Lawrence Crane, Ralph Demasi, Dennis O. Dixon, Phillipe Flandre, Michael D. Hughes, Leslie A. Kalish, Kinley Larntz, Danyu Lin, Ian C. Marschner, Alvaro Muñoz, Jeff Murray, Jim Neaton, Carla Pettinelli, Wasima Rida, Jeremy M.G. TaylorSeth L. Welles

Research output: Contribution to journalArticlepeer-review

Abstract

This paper summarizes the proceedings of an NIAID-sponsored workshop on statistical issues for HIV surrogate endpoints. The workshop brought together statisticians and clinicians in an attempt to shed light on some unresolved issues in the use of HIV laboratory markers (such as HIV RNA and CD4+ cell counts) in the design and analysis of clinical studies and in patient management. Utilizing a debate format, the workshop explored a series of specific questions dealing with the relationship between markers and clinical endpoints, and the choice of endpoints and methods of analysis in clinical studies. This paper provides the position statements from the two debaters on each issue. Consensus conclusions, based on the presentations and discussion, are outlined. While not providing final answers, we hope that these discussions have helped clarify a number of issues, and will stimulate further consideration of some of the highlighted problems. These issues will be critical in the proper assessment and use of future therapies for HIV disease.

Original languageEnglish (US)
Pages (from-to)2435-2462
Number of pages28
JournalStatistics in Medicine
Volume17
Issue number21
DOIs
StatePublished - Nov 15 1998

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

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