@article{bb46d4b207b2478cb2696afea349e096,
title = "NGF-induced axon growth is mediated by localized inactivation of GSK-3β and functions of the microtubule plus end binding protein APC",
abstract = "Little is known about how nerve growth factor (NGF) signaling controls the regulated assembly of microtubules that underlies axon growth. Here we demonstrate that a tightly regulated and localized activation of phosphatidylinositol 3-kinase (PI3K) at the growth cone is essential for rapid axon growth induced by NGF. This spatially activated PI3K signaling is conveyed downstream through a localized inactivation of glycogen synthase kinase 3β (GSK-3β). These two spatially coupled kinases control axon growth via regulation of a microtubule plus end binding protein, adenomatous polyposis coli (APC). Our results demonstrate that NGF signals are transduced to the axon cytoskeleton via activation of a conserved cell polarity signaling pathway.",
author = "Zhou, {Feng Quan} and Jiang Zhou and Shoukat Dedhar and Wu, {Yao Hong} and Snider, {William D.}",
note = "Funding Information: We are grateful to Drs. Michal Hetman, Kun-ping Lu, Dianqing Wu, Lynne Cassimeris, and Mohanish Deshmukh for providing us with DNA constructs used in this study. We thank Drs. Patricia Maness, Franck Polleux, Jay Brenman, Tushar Patel, and Mark Walzer for helpful comments on the manuscript. This study is supported by a Spinal Cord Research Foundation fellowship (F.-Q.Z.) and NIH grant NS031768 (W.D.S.). Core 5 of an NINDS funded Center grant (P30 NS045892) was used to generate some of the images. The authors of this paper have declared a conflict of interest. For details, go to http://www.neuron.org/cgi/content/full/42/6/897/DC1 . ",
year = "2004",
month = jun,
day = "24",
doi = "10.1016/j.neuron.2004.05.011",
language = "English (US)",
volume = "42",
pages = "897--912",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",
}