NF-κB function in B lymphocytes

Mary Kaileh, Ranjan Sen

Research output: Contribution to journalArticle

Abstract

NF-κB proteins were identified in the search for mechanisms that regulate B-lymphocyte-specific transcription of immunoglobulin κ light chain genes. Twenty-fiveyears later, though the function of the κB site in the enhancer remains enigmatic, NF-κB proteins have been shown to have important roles in B-cell development, maintenance, and function. In this review, we summarize the functions of NF-κB in B cells. An overview of B-cell biology that identifies stages in the life of B lymphocytes for the general reader is followed by three sections that examine the role of NF-κB family of proteins in B-cell development, mature B-cell survival and B-cell function. We endeavor throughout to suggest mechanisms and implications of the wide-ranging observations that have been made and conclude by highlighting the need to understand NF-κB-mediated gene expression in more depth.

Original languageEnglish (US)
Pages (from-to)254-271
Number of pages18
JournalImmunological Reviews
Volume246
Issue number1
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

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Keywords

  • B lymphocytes
  • BCR
  • Development
  • Function
  • NF-κB

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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