NF-ΚB as a therapeutic target in neurodegenerative diseases

Simonetta Camandola, Mark P. Mattson

Research output: Contribution to journalArticlepeer-review

Abstract

NF-κB is a transcription factor that regulates numerous physiological functions, and that is involved in the pathogenesis of various diseases. In the nervous system there is evidence supporting a dual role of NFκ in neurodegenerative diseases; activation of NFκB in neurons promotes their survival, whereas activation in glial and immune cells mediates pathological inflammatory processes. The reason for such a dichotomy lies in the complexity of the NF-κB system. Emerging research has begun to dissect the pathways leading to the activation of the different NFκB proteins, and the gene targets of NF-κB, in cells of the nervous system. In this article the authors discuss recent findings concerning the roles of NF-κB in the pathogenesis of several neurodegenerative disorders, and its potential as a pharmaceutical target for these disorders.

Original languageEnglish (US)
Pages (from-to)123-132
Number of pages10
JournalExpert Opinion on Therapeutic Targets
Volume11
Issue number2
DOIs
StatePublished - Feb 2007

Keywords

  • Alzheimer's disease
  • Neurodegeneration
  • NF-ΚB
  • NSAID

ASJC Scopus subject areas

  • Molecular Medicine
  • Biochemistry, Genetics and Molecular Biology(all)

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